{"id":"W2030592870","doi":"10.1074/jbc.m610502200","title":"Poly(ADP-ribose) Polymerase 1 Is Inhibited by a Histone H2A Variant, MacroH2A, and Contributes to Silencing of the Inactive X Chromosome","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences","keywords":"Chromatin; Biology; Molecular biology; Histone H2A; Histone; Poly ADP ribose polymerase; Polymerase; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005114971,0.0001735485,0.000504199,0.00004919896,0.00007056855,0.000009285875,0.0001444077,0.000232278,0.0002920528],"category_scores_gemma":[0.0003864994,0.0001050787,0.0001585745,0.0003068312,0.0002880978,0.00004244401,0.00006659705,0.0004558832,0.0000011875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003168728,"about_ca_system_score_gemma":0.0001149406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000210471,"about_ca_topic_score_gemma":3.303367e-7,"domain_scores_codex":[0.9985957,0.00003595669,0.0006526088,0.0001909013,0.0002628177,0.000262054],"domain_scores_gemma":[0.9985671,0.0002384604,0.0005216919,0.0001783699,0.0002540982,0.0002402474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001187174,0.0001787278,0.003489621,0.0000400527,0.0001102931,0.00007038496,0.0001689997,1.286142e-7,0.9899644,0.000006124053,0.003644458,0.001139684],"study_design_scores_gemma":[0.002344522,0.0003548548,0.006642347,0.0003632213,0.00005385094,0.0007719002,0.000285289,0.000002377924,0.986243,0.0001272236,0.002701086,0.0001103103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863583,0.007352664,0.0005233953,0.004899228,0.0001018187,0.0001370715,0.0001025316,0.00001020916,0.0005147165],"genre_scores_gemma":[0.9960854,0.0001638429,0.0002282498,0.002966782,0.0003331579,0.000002569102,0.000005106695,0.000009908171,0.0002049899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009727027,"threshold_uncertainty_score":0.4284985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0154134613918928,"score_gpt":0.299970394837644,"score_spread":0.2845569334457512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}