{"id":"W2030609112","doi":"10.1016/j.bmcl.2011.04.082","title":"Indole 5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase with nanomolar potency in cell-based subgenomic replicons (part 2): Central amino acid linker and right-hand-side SAR studies","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Linker; NS5B; Carboxamide; Stereochemistry; Indole test; ADME; Biochemistry; In vitro; Genotype; Hepacivirus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001565958,0.0002934352,0.0002899291,0.0001364162,0.0001231542,0.00018117,0.0002672299,0.000157935,0.001270829],"category_scores_gemma":[0.0001146797,0.0001416025,0.0001892293,0.0001136279,0.0001179817,0.0001358769,0.00009004489,0.0003073534,0.0002388555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002885316,"about_ca_system_score_gemma":0.0002093137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002225851,"about_ca_topic_score_gemma":0.004789143,"domain_scores_codex":[0.9999381,0.000009686681,0.000004479176,0.000008584101,0.00001264112,0.00002644528],"domain_scores_gemma":[0.9999667,0.000008396372,0.000007344941,0.000004469268,0.000004572589,0.000008497129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005209666,0.0001287813,0.00015444,0.00006808058,0.00001250117,0.00008001925,0.00005006388,0.001706667,0.9905903,0.0001857647,0.0002973319,0.006204965],"study_design_scores_gemma":[0.0001855385,0.002970981,0.001546481,0.000006946162,0.00003845105,0.0001613108,0.00002355513,0.003041526,0.9897947,0.00005006122,0.002163775,0.00001681131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935964,0.001611781,0.001722256,0.00006074931,0.00002260657,0.00004914218,0.0003726819,0.0001025913,0.002461646],"genre_scores_gemma":[0.9952101,0.0009548244,0.001357889,0.00003795055,0.000007244474,0.0000243292,0.0004442701,0.00001265026,0.001950763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002225851,"threshold_uncertainty_score":0.004425824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02691222795728049,"score_gpt":0.2479666223352384,"score_spread":0.2210543943779579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}