{"id":"W2030657828","doi":"10.1117/12.629808","title":"New fluorescent nucleobases derived from 5-alkynylpyrimidines","year":2005,"lang":"en","type":"article","venue":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nucleobase; Fluorophore; Oligonucleotide; Chemistry; Nucleic acid; Uracil; Substituent; Nucleic acid analogue; Combinatorial chemistry; Locked nucleic acid; Fluorescence; Cytosine; DNA; Stereochemistry; Nucleic acid thermodynamics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001951301,0.0002930743,0.0002172766,0.0002134986,0.000115072,0.0002439091,0.0003190968,0.0003691465,0.001086688],"category_scores_gemma":[0.0003303281,0.0001916075,0.0001626624,0.0001842845,0.0002585033,0.0003996409,0.0002333794,0.0005596739,0.0005188868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003390767,"about_ca_system_score_gemma":0.0002634653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003669067,"about_ca_topic_score_gemma":0.0008103201,"domain_scores_codex":[0.9998482,0.00001970262,0.00001606647,0.00004056266,0.00004581106,0.00002958574],"domain_scores_gemma":[0.9998833,0.00002286542,0.00003992477,0.0000116353,0.00001934054,0.00002296262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007831669,0.00001721538,0.00008733409,0.0001346324,0.000005003473,0.0001385289,0.00006247298,0.0002805284,0.9918568,0.00146811,0.00005244578,0.005818673],"study_design_scores_gemma":[0.00002884453,0.0005415764,0.0006873725,0.00001625061,0.00001629972,0.0004438637,0.00001591944,0.0005502707,0.9805649,0.0002086327,0.0169096,0.00001651093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9335216,0.01815928,0.03613995,0.0002172258,0.0002075099,0.0002463024,0.0005929283,0.0003896099,0.01052564],"genre_scores_gemma":[0.9375687,0.005764226,0.04991177,0.0001707232,0.00003806617,0.0001990622,0.0006369376,0.00005413629,0.005656287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001086688,"threshold_uncertainty_score":0.003635287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007738733006842711,"score_gpt":0.2164701519369683,"score_spread":0.2087314189301255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}