{"id":"W2030658904","doi":"10.1016/j.ijpharm.2014.06.048","title":"Design of lipotomes as a novel dual functioning nanocarrier for bioavailability enhancement of lacidipine: In-vitro and in-vivo characterization","year":2014,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Bioavailability; Chemistry; Solubility; First pass effect; Lacidipine; In vivo; Chromatography; Mannitol; Pharmacology; Drug; Dosage form; Nanocarriers; Pharmacokinetics; Organic chemistry; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001562169,0.0001608112,0.000340234,0.0003716616,0.00003063235,0.000009777442,0.0002323841,0.0001265953,0.0002217161],"category_scores_gemma":[0.0002836104,0.0001638677,0.00007672452,0.0001490963,0.0001825863,0.0002752861,0.00005552162,0.0003574859,0.000001068161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001255983,"about_ca_system_score_gemma":0.0001234749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004197696,"about_ca_topic_score_gemma":0.000001435539,"domain_scores_codex":[0.9980597,0.0002179436,0.001013617,0.0001699105,0.0003355229,0.000203287],"domain_scores_gemma":[0.9978757,0.0006427146,0.0007235422,0.00007279561,0.0006001637,0.00008509011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005121236,0.0006130806,0.006537468,0.0001050143,0.00024903,0.000006461161,0.0006456794,0.005725292,0.967104,0.0001366072,0.00001071258,0.01374544],"study_design_scores_gemma":[0.005686453,0.0002171171,0.001016457,0.00008432137,0.0000980495,0.00003758059,0.00007813243,0.02976606,0.95438,0.0002126768,0.008294987,0.0001282103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8465707,0.0002365868,0.1504832,0.0003453405,0.001780508,0.000399527,0.00009834737,0.000004594694,0.00008123106],"genre_scores_gemma":[0.9940582,0.0008045398,0.004362072,0.0004756415,0.0001849543,0.00001802426,0.00001335441,0.00001552727,0.00006770673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1474875,"threshold_uncertainty_score":0.668233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08216038766395561,"score_gpt":0.4182112266972314,"score_spread":0.3360508390332758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}