{"id":"W2030674911","doi":"10.1016/j.jmb.2005.06.053","title":"Pivotal Roles for the Receiver Domain in the Mechanism of Action of the Response Regulator RamR of Streptomyces coelicolor","year":2005,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Health Sciences Centre; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research","keywords":"Streptomyces coelicolor; DNA; Binding site; Biology; Response regulator; Biochemistry; Plasma protein binding; Phosphorylation; Cell biology; Mutant; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005881686,0.0004408712,0.0005806496,0.0002226614,0.0003004642,0.000733533,0.0004358326,0.000612163,0.001657767],"category_scores_gemma":[0.0005018359,0.000223206,0.0004001565,0.0001017127,0.000514326,0.0006665651,0.0005042254,0.0009679073,0.001072816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002353891,"about_ca_system_score_gemma":0.0002529334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002035484,"about_ca_topic_score_gemma":0.0001539251,"domain_scores_codex":[0.9998066,0.00004497233,0.00001616845,0.00004512278,0.00004387218,0.00004332534],"domain_scores_gemma":[0.9995872,0.0001299931,0.00007950902,0.00007001947,0.00003808243,0.00009519351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004366523,0.00002315554,0.000331876,0.00006038495,0.000004655712,0.0001316031,0.00003965633,0.0001700461,0.9958571,0.001203349,0.00003813334,0.001703401],"study_design_scores_gemma":[0.0001013829,0.0005388659,0.004427668,0.00002113884,0.00003125915,0.0009914304,0.0001263853,0.003775454,0.986807,0.0007271772,0.002420748,0.00003139981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977808,0.00217862,0.01704417,0.0002939897,0.00005687023,0.00002567967,0.000140997,0.0002441082,0.002207587],"genre_scores_gemma":[0.993597,0.0002720427,0.00453022,0.0001023064,0.0000251183,0.00001139982,0.0002363235,0.00004010216,0.001185516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001657767,"threshold_uncertainty_score":0.005545735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01355447816471556,"score_gpt":0.2930289198058137,"score_spread":0.2794744416410981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}