{"id":"W2030702185","doi":"10.1074/jbc.m112.391425","title":"The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Anaplastic lymphoma kinase; Crizotinib; ALK inhibitor; Protein kinase domain; Cancer research; Tyrosine kinase; Kinase; Point mutation; Small molecule; Neuroblastoma; Biology; Mutation; Chemistry; Mutant; Signal transduction; Cell biology; Biochemistry; Lung cancer; Genetics; Gene; Medicine; Cell culture","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002056093,0.0001259997,0.0002428022,0.00003631262,0.00009091065,0.00001523622,0.00008092384,0.00007082814,0.00004625361],"category_scores_gemma":[0.0009917126,0.00006604844,0.00009672215,0.0001163365,0.0002872381,0.0001283361,0.00005344006,0.0001981837,0.000002206867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008864223,"about_ca_system_score_gemma":0.00008236731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003123575,"about_ca_topic_score_gemma":3.066408e-7,"domain_scores_codex":[0.998945,0.00006124819,0.0003968286,0.00008785979,0.0002711541,0.0002379294],"domain_scores_gemma":[0.9983369,0.0006951794,0.0003701048,0.00009575087,0.0002427869,0.0002593432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002161474,0.0006702679,0.006947163,0.0000772667,0.0001828846,0.00007179076,0.0002709646,0.000004408244,0.9854765,0.00009392347,0.00005467008,0.003988693],"study_design_scores_gemma":[0.002080292,0.001351313,0.03496205,0.000128986,0.00003802126,0.0004946335,0.001005332,0.00006299128,0.9591765,0.00005996547,0.0005711648,0.00006878438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986843,0.0001198882,0.00002215468,0.0003992951,0.00005307205,0.0001269208,0.00001595102,0.000006288758,0.0005721203],"genre_scores_gemma":[0.9995555,0.0001622686,0.00003946719,0.00004365874,0.000143683,0.000004213492,0.000005326943,0.000005899748,0.00003995351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02801488,"threshold_uncertainty_score":0.2693377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02342981080940184,"score_gpt":0.2811613136749351,"score_spread":0.2577315028655333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}