{"id":"W2030702185","doi":"10.1074/jbc.m112.391425","title":"The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Anaplastic lymphoma kinase; Crizotinib; ALK inhibitor; Protein kinase domain; Cancer research; Tyrosine kinase; Kinase; Point mutation; Small molecule; Neuroblastoma; Biology; Mutation; Chemistry; Mutant; Signal transduction; Cell biology; Biochemistry; Lung cancer; Genetics; Gene; Medicine; Cell culture","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001707488,0.0002637699,0.0003128138,0.00009910424,0.0002006578,0.0002528343,0.0004574731,0.0003233764,0.001269751],"category_scores_gemma":[0.0002736624,0.0001908014,0.0002983146,0.0001195614,0.000255357,0.0002837437,0.0001695798,0.0005840998,0.0002772094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005124728,"about_ca_system_score_gemma":0.0005044799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002595876,"about_ca_topic_score_gemma":0.003249836,"domain_scores_codex":[0.9998664,0.00001812641,0.000007559736,0.0000164673,0.00006121539,0.00003025775],"domain_scores_gemma":[0.9999397,0.00001595318,0.00001497954,0.000004691208,0.000007121708,0.00001745144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000841389,0.000353147,0.001590723,0.0002481086,0.0002135072,0.0008633342,0.0001663447,0.01513136,0.9611244,0.00361801,0.001905505,0.01394419],"study_design_scores_gemma":[0.001154406,0.002295351,0.007022352,0.00004817155,0.0001567429,0.00182411,0.0001747706,0.03487773,0.9348112,0.001044223,0.01648541,0.0001054661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945474,0.001262505,0.001270322,0.0001534353,0.00002761463,0.00002289222,0.0001381901,0.00005661136,0.002521157],"genre_scores_gemma":[0.9959251,0.0006353187,0.001794682,0.00007791464,0.000004772795,0.00001621414,0.000408416,0.0000142217,0.001123367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002595876,"threshold_uncertainty_score":0.005161583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02342981080940184,"score_gpt":0.2811613136749351,"score_spread":0.2577315028655333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}