{"id":"W2030714059","doi":"10.1038/ng.392","title":"Lin28 promotes transformation and is associated with advanced human malignancies","year":2009,"lang":"en","type":"article","venue":"Nature Genetics","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":820,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute","keywords":"LIN28; Derepression; Psychological repression; microRNA; Biology; Cancer research; Carcinogenesis; Proteostasis; Malignant transformation; HMGA2; Cancer; KLF2; Oncomir; Cell biology; Genetics; Downregulation and upregulation; Gene; Gene expression; Transcription factor; SOX2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002106937,0.000341127,0.000388724,0.0009873676,0.0003075568,0.0004382732,0.0003042731,0.000524899,0.004752474],"category_scores_gemma":[0.0004413276,0.0003336822,0.0002756024,0.0004516552,0.0003839775,0.0001715581,0.0006136734,0.0009072519,0.001035823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000227344,"about_ca_system_score_gemma":0.0001916587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002402066,"about_ca_topic_score_gemma":0.0003398526,"domain_scores_codex":[0.9997428,0.00005868928,0.00001438237,0.00005822722,0.00008220506,0.00004365437],"domain_scores_gemma":[0.9993548,0.0001282487,0.0002405645,0.00008035494,0.0000315835,0.0001645751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001363995,0.0001120704,0.01763417,0.00007619627,0.00007978829,0.002116845,0.00004772835,0.0002500443,0.9698756,0.0008292102,0.0008760648,0.006738401],"study_design_scores_gemma":[0.0003039963,0.0009715655,0.3705886,0.00002912779,0.0002625119,0.02804642,0.0002149094,0.004626493,0.571013,0.002693964,0.02119895,0.0000504206],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912374,0.001954102,0.002908327,0.0002826361,0.00003960231,0.00002029627,0.0004607365,0.0003618182,0.002735014],"genre_scores_gemma":[0.9962453,0.0004517952,0.0006217042,0.00005560328,0.00002286904,0.00001971068,0.0004173855,0.00005986893,0.002105706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004752474,"threshold_uncertainty_score":0.01589864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004455062445350644,"score_gpt":0.2397715543522619,"score_spread":0.2353164919069113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}