{"id":"W2030736429","doi":"10.1210/jc.2010-0636","title":"Alendronate for the Treatment of Pediatric Osteogenesis Imperfecta: A Randomized Placebo-Controlled Study","year":2010,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":220,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; Shriners Hospitals for Children - Canada; University of Ottawa","funders":"Canadian Institutes of Health Research; Merck","keywords":"Medicine; Placebo; Osteogenesis imperfecta; Bisphosphonate; Bone mineral; Context (archaeology); Osteoporosis; N-terminal telopeptide; Incidence (geometry); Randomized controlled trial; Bone density; Urology; Hip fracture; Internal medicine; Surgery; Osteocalcin; Anatomy; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003785657,0.001327036,0.004987717,0.0007489324,0.0005657242,0.0008931065,0.001035317,0.002521013,0.004579123],"category_scores_gemma":[0.003769032,0.0007415271,0.002325188,0.000714715,0.001670922,0.000787911,0.0004465735,0.001722393,0.0004540226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006120247,"about_ca_system_score_gemma":0.001568669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006737084,"about_ca_topic_score_gemma":0.001258366,"domain_scores_codex":[0.9977545,0.001375544,0.0002462885,0.0002701464,0.0002168527,0.0001365986],"domain_scores_gemma":[0.9977143,0.0008291935,0.0006576434,0.0001985194,0.0001893587,0.0004110329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9762936,0.006508858,0.0005316387,0.001596643,0.001263621,0.00005105043,0.00002787243,0.00009483501,0.002473433,0.00005473585,0.0001827959,0.01092103],"study_design_scores_gemma":[0.9511722,0.04661832,0.0009421813,0.00005554824,0.0005752429,0.00002402102,0.000008173519,0.00008185193,0.0001946754,0.00002450458,0.0002975301,0.000005891107],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9542767,0.02803365,0.001362208,0.0009082874,0.001377881,0.01186724,0.0009622469,0.0001405545,0.001071317],"genre_scores_gemma":[0.9544179,0.01869291,0.004292943,0.001524991,0.002310246,0.01636903,0.000754711,0.00002420568,0.001613089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004987717,"threshold_uncertainty_score":0.02002072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03797264726409115,"score_gpt":0.3990287931956256,"score_spread":0.3610561459315344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}