{"id":"W2030736429","doi":"10.1210/jc.2010-0636","title":"Alendronate for the Treatment of Pediatric Osteogenesis Imperfecta: A Randomized Placebo-Controlled Study","year":2010,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":220,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; Shriners Hospitals for Children - Canada; University of Ottawa","funders":"Canadian Institutes of Health Research; Merck","keywords":"Medicine; Placebo; Osteogenesis imperfecta; Bisphosphonate; Bone mineral; Context (archaeology); Osteoporosis; N-terminal telopeptide; Incidence (geometry); Randomized controlled trial; Bone density; Urology; Hip fracture; Internal medicine; Surgery; Osteocalcin; Anatomy; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004878478,0.0002244728,0.001580959,0.00008954194,0.0001406669,0.00001023718,0.0006999093,0.0001410826,0.00007188101],"category_scores_gemma":[0.005731239,0.0001021342,0.001218543,0.0001081816,0.0005134983,0.000005097434,0.0000957438,0.0003738639,0.000003267454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004691409,"about_ca_system_score_gemma":0.000255897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000449016,"about_ca_topic_score_gemma":0.0001289816,"domain_scores_codex":[0.9955317,0.002129019,0.001477202,0.0002267746,0.0002615116,0.0003737324],"domain_scores_gemma":[0.990896,0.006879106,0.0009662206,0.0005803594,0.0005857433,0.00009250564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8617315,0.003767799,0.006843301,0.0000166601,0.008336624,0.00001770318,0.0007208871,0.00009592756,0.03837872,0.0002477198,0.0006275418,0.07921565],"study_design_scores_gemma":[0.9117783,0.007100985,0.02036458,0.000002129821,0.006638585,0.0001466267,0.0007492041,0.0001191582,0.01578405,0.0004030981,0.03667041,0.0002429326],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704502,0.02431714,0.0002838781,0.001196282,0.001079939,0.002609257,0.00001153553,0.000003218069,0.00004860726],"genre_scores_gemma":[0.9658867,0.03152413,0.000118643,0.00006742694,0.001824753,0.0002072627,0.000001830021,0.00002415364,0.0003450943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07897272,"threshold_uncertainty_score":0.6861243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03797264726409115,"score_gpt":0.3990287931956256,"score_spread":0.3610561459315344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}