{"id":"W2030760870","doi":"10.2337/diabetes.50.9.2133","title":"Depressed Levels of Ca2+-Cycling Proteins May Underlie Sarcoplasmic Reticulum Dysfunction in the Diabetic Heart","year":2001,"lang":"en","type":"article","venue":"Diabetes","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Phospholamban; Internal medicine; Endocrinology; CAMK; Ryanodine receptor; Phosphatase; Protein kinase A; Endoplasmic reticulum; Calsequestrin; Diabetes mellitus; Streptozotocin; Calmodulin; Chemistry; Phosphorylation; Biology; Calcium; Medicine; Biochemistry; Autophosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002076392,0.0004747602,0.0003321806,0.0003315617,0.000126975,0.0002398062,0.0002037001,0.0003388888,0.0005689117],"category_scores_gemma":[0.0001051241,0.0001888268,0.0002235683,0.0001964945,0.0002958561,0.0002123724,0.0001642721,0.0005691677,0.00009157718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001398785,"about_ca_system_score_gemma":0.00009061651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002758358,"about_ca_topic_score_gemma":0.000360181,"domain_scores_codex":[0.999945,0.000006828321,0.00001017778,0.00001421522,0.00001035782,0.00001336682],"domain_scores_gemma":[0.999899,0.000006983292,0.00004756647,0.000005856255,0.000006199528,0.00003431578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002259978,0.000225396,0.0188068,0.0001400214,0.00004773816,0.001289572,0.00007379277,0.0001067723,0.9733461,0.0001256336,0.00004794768,0.003530388],"study_design_scores_gemma":[0.000314652,0.002486371,0.735163,0.00003568623,0.0002660742,0.006391865,0.0003354802,0.00216927,0.2512466,0.0006717982,0.0008900364,0.00002914554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980288,0.0009588122,0.0006433623,0.00003190445,0.00000953672,0.00001058711,0.00004888654,0.00001538746,0.0002527647],"genre_scores_gemma":[0.9982489,0.0008372124,0.0004613703,0.00003451738,0.00001274934,0.00001380187,0.0001239392,0.0000030509,0.0002643629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005689117,"threshold_uncertainty_score":0.001903236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01689846300538324,"score_gpt":0.2543557717265001,"score_spread":0.2374573087211168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}