{"id":"W2030761095","doi":"10.1016/j.bmc.2007.11.007","title":"Estradiol and estrone C-16 derivatives as inhibitors of type 1 17β-hydroxysteroid dehydrogenase: Blocking of ER+ breast cancer cell proliferation induced by estrone","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Estrone; Chemistry; Estrogen; Hydroxysteroid dehydrogenase; Estrogen receptor; Cell growth; IC50; Endogeny; Pharmacology; Internal medicine; Breast cancer; Cancer cell; Endocrinology; Stereochemistry; Dehydrogenase; Enzyme; Biochemistry; In vitro; Cancer; Hormone; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001889875,0.0003557008,0.000322853,0.0003299372,0.0001497374,0.000202809,0.0003097898,0.0002323747,0.0019814],"category_scores_gemma":[0.0001267827,0.0002297957,0.000196727,0.0002764052,0.0002492468,0.0001942756,0.0001571877,0.0003539216,0.0004036466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002043564,"about_ca_system_score_gemma":0.0002603311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008651221,"about_ca_topic_score_gemma":0.001596438,"domain_scores_codex":[0.9999367,0.00001382806,0.000006173366,0.000006399755,0.00001069076,0.00002609538],"domain_scores_gemma":[0.999948,0.00001164677,0.00001133731,0.000006783737,0.000005375433,0.00001683243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004523282,0.0004190318,0.0006705452,0.0003022761,0.00005225247,0.0007178665,0.0001288084,0.00183035,0.9594274,0.002102034,0.000809729,0.02901641],"study_design_scores_gemma":[0.0003716788,0.002413224,0.001817411,0.0000170345,0.00005411282,0.0005100496,0.00002532652,0.0006124788,0.9819391,0.00009312508,0.01212955,0.0000168711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772258,0.01278753,0.001305428,0.0001624141,0.000134228,0.00007254731,0.0003795924,0.0001195695,0.007812927],"genre_scores_gemma":[0.9797577,0.01016166,0.001045467,0.00009346344,0.0000316471,0.00004584951,0.0003983438,0.00001946752,0.00844638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0019814,"threshold_uncertainty_score":0.006628454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00455009675449668,"score_gpt":0.2335389251828969,"score_spread":0.2289888284284002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}