{"id":"W2030775866","doi":"10.1016/j.molcel.2014.04.004","title":"Accessibility of Different Histone H3-Binding Domains of UHRF1 Is Allosterically Regulated by Phosphatidylinositol 5-Phosphate","year":2014,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Cancer Research UK; Wellcome Trust","keywords":"Biology; Histone; Allosteric regulation; Phosphatidylinositol; Phosphate; Histone H3; Biochemistry; Cell biology; Signal transduction; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002384226,0.0001906679,0.0002737384,0.000171574,0.0003714628,0.0003854864,0.0005096634,0.0002887209,0.00439745],"category_scores_gemma":[0.0003678104,0.0002572533,0.0004395786,0.0001298155,0.0004712213,0.0003661739,0.0005349518,0.0004888787,0.0007847935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004951002,"about_ca_system_score_gemma":0.000166678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001630381,"about_ca_topic_score_gemma":0.002353176,"domain_scores_codex":[0.9998038,0.00001945148,0.000008268652,0.00005828689,0.00002959314,0.00008070292],"domain_scores_gemma":[0.9998709,0.00003066262,0.0000318345,0.00001620976,0.00001231077,0.00003811141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001018558,0.00002909881,0.000924331,0.00003328866,0.00001710916,0.00004192534,0.00004311555,0.0001239432,0.9951912,0.0004587881,0.0001398014,0.001978868],"study_design_scores_gemma":[0.0001236124,0.0001225947,0.03502993,0.000009603739,0.00002981504,0.0002081152,0.0001153388,0.004573385,0.9578574,0.0003882575,0.001510506,0.00003147095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954679,0.0005137507,0.002065569,0.0001178889,0.0000306945,0.00000574346,0.0001541552,0.00008570402,0.001558564],"genre_scores_gemma":[0.9987038,0.00008114573,0.0004094712,0.0000472722,0.000004042073,0.000004739735,0.0001358544,0.00001674736,0.0005969931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00439745,"threshold_uncertainty_score":0.01471096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007340960563729201,"score_gpt":0.2613515655611262,"score_spread":0.254010604997397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}