{"id":"W2030826846","doi":"10.1161/circulationaha.112.121830","title":"Transient Receptor Potential Canonical-3 Channel–Dependent Fibroblast Regulation in Atrial Fibrillation","year":2012,"lang":"en","type":"article","venue":"Circulation","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":265,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"Canadian Institutes of Health Research; Mitacs; Heart Rhythm Society; Japan Heart Foundation; Fondation Leducq; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada","keywords":"TRPC3; Fibroblast; NFAT; Extracellular; Molecular biology; Cell biology; Signal transduction; Biology; Endocrinology; Internal medicine; Medicine; TRPC; Transient receptor potential channel; Cell culture; Receptor; Transplantation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003330231,0.000161954,0.0001655756,0.0001986674,0.0001572166,0.00004456856,0.00008570314,0.000184462,0.0003356047],"category_scores_gemma":[0.0001378324,0.0001602666,0.0001427599,0.0003783705,0.00004343281,0.0006025124,0.00002367133,0.0001308526,0.0001676656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002182276,"about_ca_system_score_gemma":0.00004207819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004214693,"about_ca_topic_score_gemma":0.00001001813,"domain_scores_codex":[0.9981674,0.0002103613,0.0004121208,0.0003533209,0.0004489589,0.0004078551],"domain_scores_gemma":[0.9994707,0.00006993687,0.000154878,0.000140947,0.0000382425,0.0001253736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001426196,0.00004726551,0.002589561,0.00002605977,0.000004542776,9.408583e-7,0.001318401,0.2693443,0.7202682,0.0009099824,0.0001358319,0.005212253],"study_design_scores_gemma":[0.004648182,0.0001440427,0.2659628,0.0002256414,0.0000535574,0.00007283015,0.0002830285,0.2075167,0.5132216,0.001167921,0.005425098,0.001278555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888414,0.0000719392,0.006881808,0.0003607847,0.002742253,0.000520773,0.0000126087,0.00008604359,0.0004824501],"genre_scores_gemma":[0.9975487,0.00002629246,0.00004824711,0.00003515098,0.002147919,0.000006445733,0.00005476026,0.00002539957,0.000107067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2633733,"threshold_uncertainty_score":0.6535481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02783272936677256,"score_gpt":0.2552164984525944,"score_spread":0.2273837690858218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}