{"id":"W2030849371","doi":"10.1074/jbc.m110.173526","title":"Structural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin Ligase","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Novo Nordisk Fonden; Vetenskapsrådet; Sultan Qaboos University; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Cancerfonden; Stiftelsen för Strategisk Forskning; Novo Nordisk; Skånes universitetssjukhus; Ontario Genomics Institute; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust","keywords":"SOCS6; SOCS3; Ubiquitin ligase; Suppressor of cytokine signaling 1; SOCS5; Ubiquitin; Suppressor of cytokine signalling; Suppressor; Chemistry; Cytokine; SOCS2; Cell biology; Biology; Biochemistry; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007926901,0.0002255292,0.0001742058,0.00007526788,0.0001905862,0.0001887226,0.0002460965,0.0002475975,0.0009597666],"category_scores_gemma":[0.00008179514,0.00009467534,0.0002275947,0.00005337918,0.000208697,0.0001554855,0.0002109381,0.0003193674,0.0002795452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000275235,"about_ca_system_score_gemma":0.0002193212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003423259,"about_ca_topic_score_gemma":0.0003061876,"domain_scores_codex":[0.9999422,0.000009253294,0.00000418031,0.000009330529,0.00001996107,0.00001517493],"domain_scores_gemma":[0.9999583,0.000004460489,0.00001423569,0.000002160082,0.00000560458,0.00001530594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003879806,0.00008386253,0.001258336,0.0001315851,0.00002927594,0.0006837557,0.00003659398,0.003302983,0.9869171,0.003423095,0.0004105195,0.003334815],"study_design_scores_gemma":[0.0003614468,0.001257069,0.02477175,0.00004348665,0.00008008738,0.003829757,0.0001499106,0.06234229,0.8901499,0.002823937,0.01414345,0.00004699051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919258,0.001359618,0.003592498,0.0002110897,0.00004858404,0.00002547908,0.0001489944,0.00009756535,0.002590477],"genre_scores_gemma":[0.9978332,0.0004074732,0.001035289,0.00006869887,0.000006885914,0.000007574376,0.0001442776,0.000005400632,0.000491278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009597666,"threshold_uncertainty_score":0.003210723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02253926079041732,"score_gpt":0.2794855608885924,"score_spread":0.2569463000981751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}