{"id":"W2030849371","doi":"10.1074/jbc.m110.173526","title":"Structural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin Ligase","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Novo Nordisk Fonden; Vetenskapsrådet; Sultan Qaboos University; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Cancerfonden; Stiftelsen för Strategisk Forskning; Novo Nordisk; Skånes universitetssjukhus; Ontario Genomics Institute; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust","keywords":"SOCS6; SOCS3; Ubiquitin ligase; Suppressor of cytokine signaling 1; SOCS5; Ubiquitin; Suppressor of cytokine signalling; Suppressor; Chemistry; Cytokine; SOCS2; Cell biology; Biology; Biochemistry; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003286506,0.0001028924,0.0002919176,0.000011959,0.00004802328,0.00001043933,0.00009742116,0.0001435181,0.0007065515],"category_scores_gemma":[0.0002457099,0.00005303257,0.0002292692,0.00005147156,0.00009587274,0.00002741774,0.00001811532,0.0003732669,2.310371e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002193352,"about_ca_system_score_gemma":0.00004530233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003305821,"about_ca_topic_score_gemma":3.663248e-7,"domain_scores_codex":[0.9992092,0.00001183104,0.0003862571,0.0000996729,0.0001524967,0.0001405291],"domain_scores_gemma":[0.9990765,0.0001613469,0.000358385,0.0001073164,0.0002034877,0.00009294398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006716066,0.00004908671,0.00012606,0.00004903722,0.00004316973,0.000008452144,0.0000304281,0.000001050783,0.9973263,0.00004436735,0.0005652264,0.001085212],"study_design_scores_gemma":[0.001248948,0.0004413813,0.0001493879,0.00006889406,0.00004699504,0.0003084829,0.0001137679,0.00002191275,0.9945647,0.00134305,0.001629457,0.00006303385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977285,0.0002433498,0.0001873168,0.001426341,0.0001111426,0.000107374,0.00009815094,0.000006239323,0.00009156687],"genre_scores_gemma":[0.9977111,0.00003590478,0.001146803,0.0002883882,0.0007347251,0.000004966389,0.00001860013,0.000007528858,0.00005193552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002761613,"threshold_uncertainty_score":0.7736244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02253926079041732,"score_gpt":0.2794855608885924,"score_spread":0.2569463000981751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}