{"id":"W2030855312","doi":"10.1111/j.1462-5822.2006.00762.x","title":"Salmonella enterica serovar Typhimurium effectors SopB, SopE, SopE2 and SipA disrupt tight junction structure and function","year":2006,"lang":"en","type":"article","venue":"Cellular Microbiology","topic":"Salmonella and Campylobacter epidemiology","field":"Agricultural and Biological Sciences","cited_by":201,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Michael Smith Health Research BC; Howard Hughes Medical Institute","keywords":"Salmonella enterica; Biology; Tight junction; Effector; Secretion; Cell biology; Occludin; Cell polarity; Salmonella; Barrier function; Microbiology; Mutant; Type three secretion system; Cell; Genetics; Gene; Biochemistry; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001107786,0.000414469,0.0001629549,0.0001958726,0.000111514,0.0002975307,0.0001133051,0.0002579604,0.0005572004],"category_scores_gemma":[0.0001127146,0.0001550493,0.0001930285,0.00007720851,0.0001845847,0.0001757245,0.0002671018,0.0002982116,0.0002127051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001744064,"about_ca_system_score_gemma":0.0001684813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004970545,"about_ca_topic_score_gemma":0.0005702029,"domain_scores_codex":[0.9998846,0.000027317,0.000009372996,0.00001201168,0.00002887273,0.00003776636],"domain_scores_gemma":[0.9998926,0.00001563193,0.00003813711,0.0000118948,0.000009753582,0.00003189524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006309953,0.00001434796,0.0004836206,0.00001100812,0.000003061302,0.00003791347,0.000007469763,0.00005088297,0.998847,0.00003814576,0.00001356664,0.0004297892],"study_design_scores_gemma":[0.00001447853,0.0004233978,0.01792084,0.000006811042,0.00001850759,0.0006826989,0.0001066776,0.001548629,0.9777313,0.00006950848,0.001471127,0.000005959621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988507,0.0002630449,0.0005040876,0.00002017109,0.000003055992,0.000002810816,0.00003284753,0.00002077068,0.0003024693],"genre_scores_gemma":[0.9983176,0.0002598225,0.0006772379,0.00002272353,0.000001686309,0.000004206349,0.0001211119,0.000008039332,0.0005876116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005572004,"threshold_uncertainty_score":0.001864076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004399899405340764,"score_gpt":0.1637178094483447,"score_spread":0.1593179100430039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}