{"id":"W2030855312","doi":"10.1111/j.1462-5822.2006.00762.x","title":"Salmonella enterica serovar Typhimurium effectors SopB, SopE, SopE2 and SipA disrupt tight junction structure and function","year":2006,"lang":"en","type":"article","venue":"Cellular Microbiology","topic":"Salmonella and Campylobacter epidemiology","field":"Agricultural and Biological Sciences","cited_by":201,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Michael Smith Health Research BC; Howard Hughes Medical Institute","keywords":"Salmonella enterica; Biology; Tight junction; Effector; Secretion; Cell biology; Occludin; Cell polarity; Salmonella; Barrier function; Microbiology; Mutant; Type three secretion system; Cell; Genetics; Gene; Biochemistry; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001915305,0.0002967985,0.0003915789,0.0000285203,0.0002367209,0.00004144389,0.0001258978,0.0003917167,0.0002601112],"category_scores_gemma":[0.00001934688,0.0001316691,0.00007919209,0.0001674334,0.0002545526,0.00007530487,0.0001250261,0.0002039788,0.00003582118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002403293,"about_ca_system_score_gemma":0.000005164303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003289554,"about_ca_topic_score_gemma":0.0002102419,"domain_scores_codex":[0.998264,0.000313848,0.0003114697,0.00063143,0.00003952542,0.0004396977],"domain_scores_gemma":[0.9994298,0.0001941528,0.0001450719,0.0000936775,0.00004475667,0.00009253884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008135271,0.00003164701,0.05355294,0.00001435514,0.00002375049,0.000006928964,0.00001341444,0.00000205129,0.9393523,0.0001378371,0.001408734,0.005374723],"study_design_scores_gemma":[0.0009830771,0.001365575,0.6815684,0.0000311002,0.0001866686,0.0005032289,0.0001381715,0.00008832751,0.1328124,0.003558296,0.1778093,0.0009554198],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957353,0.002453518,0.00007762788,0.0004616142,0.0006748424,0.0002487593,0.00005877168,0.00008118424,0.0002084074],"genre_scores_gemma":[0.9975331,0.0000915723,0.00006073383,0.0003865114,0.0005688,0.000008444628,0.0008277878,0.000003912391,0.0005190898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8065398,"threshold_uncertainty_score":0.536931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004399899405340764,"score_gpt":0.1637178094483447,"score_spread":0.1593179100430039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}