{"id":"W2030863517","doi":"10.1002/biot.200500039","title":"Yeast as a tool to uncover the cellular targets of drugs","year":2006,"lang":"en","type":"review","venue":"Biotechnology Journal","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Yeast; Saccharomyces cerevisiae; Computational biology; Drug; Biology; Gene; Mechanism (biology); Model organism; Drug action; Organism; Gene expression; Mechanism of action; Genetics; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008617756,0.001249823,0.001902985,0.003626637,0.0003721822,0.001403859,0.00106974,0.001397928,0.001936311],"category_scores_gemma":[0.0004492446,0.0004933637,0.0006272921,0.00250265,0.0007619576,0.001106629,0.0007648916,0.001969507,0.004449482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009707428,"about_ca_system_score_gemma":0.0006902654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009692523,"about_ca_topic_score_gemma":0.001134139,"domain_scores_codex":[0.9995097,0.00007395888,0.00004692834,0.00007029143,0.0002695967,0.00002946328],"domain_scores_gemma":[0.9997647,0.00007894546,0.00003272952,0.00002059101,0.00007644779,0.00002652308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000175004,0.0001536572,0.0003617918,0.01018628,0.0001085165,0.0009865055,0.0001240752,0.001108458,0.06258635,0.01933083,0.02404083,0.8808379],"study_design_scores_gemma":[0.00003429536,0.0001564767,0.0005029824,0.000738045,0.0000617107,0.001792366,0.00004189308,0.0002035134,0.01493876,0.002800929,0.9787039,0.00002512301],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007625142,0.9892101,0.003648258,0.000504288,0.0004219379,0.00003236441,0.00007687578,0.0001037212,0.005240039],"genre_scores_gemma":[0.003408693,0.9875284,0.005498221,0.0003817231,0.0001355984,0.00004677252,0.0001289249,0.00001383849,0.00285793],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003626637,"threshold_uncertainty_score":0.007043242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.014608615839588,"score_gpt":0.2984764918145162,"score_spread":0.2838678759749282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}