{"id":"W2030872041","doi":"10.1371/journal.pone.0012734","title":"Novel GLP-1 Fusion Chimera as Potent Long Acting GLP-1 Receptor Agonist","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Glucagon-like peptide 1 receptor; Agonist; Exenatide; Endocrinology; Internal medicine; Glucose homeostasis; Liraglutide; Receptor; Streptozotocin; Pharmacology; Chemistry; Insulin; Chimera (genetics); Diabetes mellitus; Type 2 diabetes; Medicine; Insulin resistance; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001163343,0.000280493,0.0003206239,0.0001201305,0.0001153675,0.0002988096,0.0003656719,0.0004713938,0.001119904],"category_scores_gemma":[0.00005740396,0.0001235245,0.000243666,0.0001487819,0.0001209773,0.0002365069,0.0002149181,0.0008443253,0.0004536817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003627498,"about_ca_system_score_gemma":0.0001297546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004267715,"about_ca_topic_score_gemma":0.0004015658,"domain_scores_codex":[0.9999139,0.00001342995,0.000005525248,0.00002110918,0.00002191175,0.00002410629],"domain_scores_gemma":[0.999976,0.000002020872,0.000005864452,0.000002471146,0.000003300466,0.00001031429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000211193,0.00007028614,0.00007631919,0.00004660003,0.0000141751,0.0001344748,0.00001495697,0.000209066,0.9961271,0.0001719429,0.0002829405,0.002641075],"study_design_scores_gemma":[0.0001723556,0.001150108,0.00172615,0.00001156978,0.00007928634,0.001446733,0.00002473215,0.004385654,0.9714054,0.0000775116,0.0194947,0.00002587701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747775,0.006912441,0.01291743,0.0005212295,0.0001450443,0.00009329357,0.0007936565,0.000432369,0.003407095],"genre_scores_gemma":[0.9845898,0.002299356,0.006328685,0.0002631227,0.00002800012,0.00009089566,0.001292275,0.00004385922,0.005064064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001119904,"threshold_uncertainty_score":0.00374645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03191684777274422,"score_gpt":0.244981768234909,"score_spread":0.2130649204621648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}