{"id":"W2030873172","doi":"10.1038/sj.leu.2402114","title":"Nucleoside analogues: mechanisms of drug resistance and reversal strategies","year":2001,"lang":"en","type":"review","venue":"Leukemia","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":492,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; Ligue Contre le Cancer; Alberta Cancer Foundation; Friedreich's Ataxia Research Alliance","keywords":"Nucleoside transporter; Nucleoside analogue; Cladribine; Nucleoside; Fludarabine; Pharmacology; Intracellular; Transporter; Drug resistance; Gemcitabine; ATP-binding cassette transporter; Deoxycytidine kinase; Mechanism of action; Drug; Biology; Cancer research; Biochemistry; In vitro; Chemotherapy; Deoxycytidine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007289706,0.00103225,0.001689464,0.00135798,0.0003236663,0.001296148,0.001300588,0.00145815,0.002898958],"category_scores_gemma":[0.0007312751,0.0003058293,0.0003651489,0.001561544,0.0007066022,0.001413358,0.0004164207,0.002281149,0.002094233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008264199,"about_ca_system_score_gemma":0.000662473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007722261,"about_ca_topic_score_gemma":0.002002747,"domain_scores_codex":[0.9998417,0.00002998798,0.00002341646,0.00003166691,0.00005730546,0.00001599382],"domain_scores_gemma":[0.999698,0.0001747757,0.00003717019,0.00001224543,0.00005206623,0.00002565116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001915585,0.0001068117,0.0001594974,0.003932753,0.00004691563,0.0005555921,0.00005841212,0.0007885562,0.005708026,0.005947472,0.02327693,0.9592273],"study_design_scores_gemma":[0.00006897598,0.0001815662,0.0004937487,0.000728177,0.00008267981,0.002763575,0.00005567183,0.0002193926,0.002677784,0.003503442,0.9892036,0.00002134986],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002924851,0.9968747,0.0004481548,0.0004032159,0.0002532462,0.000007148873,0.00001905095,0.00001468474,0.001687285],"genre_scores_gemma":[0.001363892,0.9963841,0.0005443461,0.0002778361,0.0002434388,0.00001378065,0.00003069062,0.00000244993,0.001139343],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002898958,"threshold_uncertainty_score":0.009697974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01701804877374928,"score_gpt":0.2768646023809644,"score_spread":0.2598465536072151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}