{"id":"W2030917262","doi":"10.1371/journal.ppat.1000143","title":"Stable Cytotoxic T Cell Escape Mutation in Hepatitis C Virus Is Linked to Maintenance of Viral Fitness","year":2008,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Hepatitis C virus research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institute of Allergy and Infectious Diseases; Starr Foundation; Greenberg Medical Research Institute; National Center for Research Resources; Cancer Research Institute; Ellison Medical Foundation","keywords":"Biology; Viral quasispecies; Virology; Epitope; Viral replication; Cytotoxic T cell; Major histocompatibility complex; Hepatitis C virus; Virus; CD8; T cell; Antigen; Immune system; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001837933,0.0002175494,0.0002373391,0.0001870057,0.0001443175,0.0002307334,0.0001198438,0.0003136933,0.0005373793],"category_scores_gemma":[0.0002382619,0.0001114344,0.0001593823,0.0001320621,0.0002958697,0.0001278809,0.0001556402,0.0003661896,0.000152745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002527618,"about_ca_system_score_gemma":0.0001344763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003473491,"about_ca_topic_score_gemma":0.0002622248,"domain_scores_codex":[0.9998318,0.00005369094,0.00001790341,0.00002719347,0.00003716233,0.00003219234],"domain_scores_gemma":[0.9998081,0.00005101316,0.00005753313,0.00002568944,0.00001931013,0.00003831565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002214554,0.00005355092,0.001742555,0.00002391414,0.000006698038,0.0001880767,0.00002005635,0.0001239711,0.9959593,0.00007109549,0.00001405714,0.001575306],"study_design_scores_gemma":[0.00008183179,0.004401996,0.07498198,0.00001824128,0.00006108693,0.004351412,0.00008623761,0.004416389,0.9100243,0.0003225959,0.001228497,0.00002546174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989154,0.000388577,0.000392557,0.00001033656,0.000003963292,0.000008791313,0.00002152228,0.00001296069,0.0002459396],"genre_scores_gemma":[0.9994722,0.0001307435,0.0001728653,0.000009147207,0.000004055837,0.000006344877,0.00003909117,0.000003484835,0.0001620241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005373793,"threshold_uncertainty_score":0.001833975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03717034382422386,"score_gpt":0.2846940005900175,"score_spread":0.2475236567657936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}