{"id":"W2030917262","doi":"10.1371/journal.ppat.1000143","title":"Stable Cytotoxic T Cell Escape Mutation in Hepatitis C Virus Is Linked to Maintenance of Viral Fitness","year":2008,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Hepatitis C virus research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institute of Allergy and Infectious Diseases; Starr Foundation; Greenberg Medical Research Institute; National Center for Research Resources; Cancer Research Institute; Ellison Medical Foundation","keywords":"Biology; Viral quasispecies; Virology; Epitope; Viral replication; Cytotoxic T cell; Major histocompatibility complex; Hepatitis C virus; Virus; CD8; T cell; Antigen; Immune system; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002266287,0.0001903031,0.0004837359,0.0003750064,0.00006805737,0.000008939109,0.0001606049,0.0001399061,0.0005760039],"category_scores_gemma":[0.000377255,0.0001904037,0.00009651139,0.000693378,0.00009250054,0.0001205429,0.00008173534,0.0002803309,0.0004354367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002469524,"about_ca_system_score_gemma":0.0002943127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002044172,"about_ca_topic_score_gemma":0.001091399,"domain_scores_codex":[0.997716,0.0001133198,0.0005102351,0.0004051561,0.0007005964,0.0005546595],"domain_scores_gemma":[0.9987822,0.00008856011,0.00009451429,0.0004619309,0.0003161978,0.0002565894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001673491,0.0005280803,0.277487,0.0002090494,0.00002290667,0.001190641,0.002770687,0.00004657456,0.7152608,0.00001226973,0.0008199113,0.001484718],"study_design_scores_gemma":[0.002582815,0.001030266,0.3607148,0.0003711939,0.00004197293,0.00004366392,0.000111747,0.007746187,0.6255364,0.00008141928,0.00137659,0.0003629376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948412,0.00009251028,0.0002831165,0.0002662266,0.00005285172,0.0009598507,0.0003352184,0.00004693291,0.003122116],"genre_scores_gemma":[0.9942902,0.000631429,0.002788864,0.0005099743,0.00006735686,0.000136406,0.0000499125,0.0000522679,0.001473641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08972438,"threshold_uncertainty_score":0.7764436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03717034382422386,"score_gpt":0.2846940005900175,"score_spread":0.2475236567657936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}