{"id":"W2030939957","doi":"10.1371/journal.pgen.1002822","title":"A Positive Feedback Loop Links Opposing Functions of P-TEFb/Cdk9 and Histone H2B Ubiquitylation to Regulate Transcript Elongation in Fission Yeast","year":2012,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Clinical Research Institute","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; National Cancer Institute; Fonds de Recherche du Québec - Santé; Fundación Caja Madrid","keywords":"Histone H2B; Biology; Chromatin immunoprecipitation; RNA polymerase II; Histone methyltransferase; Histone H2A; Histone code; Chromatin; P-TEFb; Histone; Histone H3; Cell biology; Histone methylation; Histone H1; Molecular biology; Genetics; DNA methylation; Gene expression; Nucleosome; Gene; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001140778,0.0001230713,0.0001337006,0.00007379014,0.00005622351,0.00001317345,0.00006533637,0.0002075579,0.000006166826],"category_scores_gemma":[0.00002296082,0.0001362833,0.00003654421,0.0001039595,0.00003949673,0.000006314976,0.00005657023,0.00009095373,0.000002958021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003777195,"about_ca_system_score_gemma":0.00003250385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008822138,"about_ca_topic_score_gemma":0.00005217918,"domain_scores_codex":[0.9992079,0.00004449642,0.0002530779,0.0001957559,0.0001022339,0.0001965458],"domain_scores_gemma":[0.9995347,0.000006718077,0.00008726084,0.0001839513,0.00008398572,0.0001034185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005148278,0.0001207495,0.00528881,0.00003296121,0.00002091862,2.141416e-7,0.0006272126,0.0007368864,0.9898626,0.00001999842,0.00004406268,0.003194162],"study_design_scores_gemma":[0.0006803799,0.0003766845,0.09772776,0.00009215983,0.00007518053,0.000009926108,0.0002377268,0.01048258,0.8894489,0.00006910412,0.0005301917,0.0002693874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959913,0.0007235339,0.002506196,0.0001519619,0.000113646,0.0002593482,0.00004789526,0.000005373401,0.0002007502],"genre_scores_gemma":[0.9967102,0.0001203205,0.002564955,0.00007492265,0.0001092979,0.000009328426,0.0001869591,0.00002296769,0.0002010006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1004136,"threshold_uncertainty_score":0.5557472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235662212431151,"score_gpt":0.2392721825951571,"score_spread":0.2269155604708456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}