{"id":"W2030963502","doi":"10.1021/jm500544p","title":"Prodrug-Inspired Probes Selective to Cathepsin B over Other Cysteine Cathepsins","year":2014,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Lakehead University; Thunder Bay Regional Research Institute","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Cathepsin; Cathepsin B; Proteases; Prodrug; Chemistry; Cysteine; Cysteine protease; Biochemistry; Cathepsin S; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002724737,0.0004858378,0.0003759378,0.0001721761,0.00009743626,0.000284468,0.000311106,0.0005659892,0.0006680431],"category_scores_gemma":[0.0002059424,0.000170055,0.0002242838,0.0001345581,0.0002210938,0.000342757,0.0001723867,0.0005945981,0.0002564699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002756231,"about_ca_system_score_gemma":0.0001496635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001936709,"about_ca_topic_score_gemma":0.0003124927,"domain_scores_codex":[0.9998659,0.00003102577,0.000006955107,0.00003348639,0.00003012897,0.00003250162],"domain_scores_gemma":[0.99992,0.00001801038,0.00002562634,0.000008379726,0.00001339644,0.00001464901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009253189,0.00003992798,0.00005172665,0.00008344681,0.00000444785,0.0001043613,0.00002331054,0.0003111103,0.9957386,0.0003424985,0.00008214125,0.003125892],"study_design_scores_gemma":[0.0000324489,0.00075222,0.0002986631,0.000005566128,0.000008372466,0.0002682811,0.00001091007,0.000680364,0.9957817,0.00006253904,0.002091578,0.000007342162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9502078,0.00601451,0.03719797,0.0003476663,0.00008389608,0.0002784013,0.000400221,0.0001927632,0.005276732],"genre_scores_gemma":[0.9699646,0.00244804,0.02315263,0.0002260508,0.00002337833,0.0001307172,0.0003184482,0.00002130818,0.003714956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006680431,"threshold_uncertainty_score":0.002234817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005121150906962519,"score_gpt":0.236791080096508,"score_spread":0.2316699291895454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}