{"id":"W2031027392","doi":"10.1016/j.bbadis.2011.06.003","title":"Niemann-Pick Type C1 deficiency in microglia does not cause neuron death in vitro","year":2011,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Ara Parseghian Medical Research Foundation","keywords":"NPC1; Microglia; Neurodegeneration; Biology; Neuroscience; Immunology; Cell biology; Inflammation; Medicine; Pathology; Endosome; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005485867,0.0007245813,0.0006762143,0.0005899002,0.0006104431,0.0006934035,0.0006751161,0.000733063,0.001951973],"category_scores_gemma":[0.0005009376,0.0003730312,0.0005724034,0.0003893406,0.0003491349,0.0004456464,0.0004647041,0.001054905,0.001454742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000713659,"about_ca_system_score_gemma":0.0006813114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003870247,"about_ca_topic_score_gemma":0.005982216,"domain_scores_codex":[0.9992743,0.0001714653,0.00008650587,0.00007770029,0.0001961837,0.0001938056],"domain_scores_gemma":[0.9994154,0.000189489,0.00005924383,0.0001425959,0.00009427091,0.00009906188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009412783,0.0001467246,0.00037461,0.0001417868,0.00003527475,0.0005106562,0.0001261919,0.0001152382,0.9956579,0.0002411001,0.0003054419,0.001403878],"study_design_scores_gemma":[0.00009239814,0.0005835962,0.004962881,0.0000416959,0.0000691317,0.001462032,0.0001459362,0.0008409858,0.9856136,0.0002486344,0.005924731,0.00001444868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814203,0.007061412,0.002173155,0.000386361,0.0002276119,0.00007050503,0.002040823,0.00009749144,0.006522302],"genre_scores_gemma":[0.9804657,0.003021834,0.002638502,0.0001458448,0.0000517531,0.0001585886,0.004727264,0.00006306211,0.008727417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003870247,"threshold_uncertainty_score":0.007695436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02850569026517986,"score_gpt":0.2856985846971069,"score_spread":0.2571928944319271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}