{"id":"W2031035517","doi":"10.1371/journal.pone.0005223","title":"Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Phytochemical compounds biological activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":291,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; Health Sciences Centre; McGill University","funders":"National Institute of General Medical Sciences; National Institutes of Health; Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance","keywords":"Translation (biology); Biology; Angiogenesis; Eukaryotic translation; EIF4E; In vivo; Eukaryotic initiation factor; Initiation factor; eIF4A; Mechanism of action; Cell biology; Cancer research; Biochemistry; In vitro; Messenger RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004675467,0.0001743213,0.00008102317,0.00017392,0.00006819553,0.0001358389,0.0000949502,0.0001538938,0.001618594],"category_scores_gemma":[0.00004011963,0.00003536873,0.0001068586,0.00009293017,0.0001181008,0.0001074149,0.00004807151,0.000209371,0.000224756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001922953,"about_ca_system_score_gemma":0.0000925514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002607131,"about_ca_topic_score_gemma":0.0003492711,"domain_scores_codex":[0.9999833,0.000003453989,9.076747e-7,0.000003698267,0.000003616637,0.000005007235],"domain_scores_gemma":[0.999972,0.000005302877,0.00001022262,0.000002239419,0.000004523074,0.000005661677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004770019,0.0001006354,0.0005946012,0.0001042262,0.00000683072,0.00007094678,0.000007189938,0.0002984556,0.9892595,0.0002918571,0.00007514893,0.008713618],"study_design_scores_gemma":[0.00008166202,0.002610201,0.01680906,0.00002345939,0.00003867548,0.0004226717,0.00002049086,0.001187782,0.9700678,0.0002224326,0.00850821,0.000007569732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810332,0.01200153,0.001874591,0.0001858158,0.00003146341,0.00004830451,0.0005631683,0.0000536994,0.004208133],"genre_scores_gemma":[0.9941268,0.002601277,0.0007856711,0.00005775851,0.0000155922,0.00001486401,0.0003506994,0.000004098425,0.002043192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001618594,"threshold_uncertainty_score":0.005414724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03479022745313445,"score_gpt":0.2356868534410065,"score_spread":0.200896625987872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}