{"id":"W2031042559","doi":"10.1016/j.ymgme.2006.01.005","title":"Heparin cofactor II–thrombin complex in MPS I: A biomarker of MPS disease","year":2006,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's & Women's Health Centre of British Columbia; Child and Family Research Institute; University of British Columbia","funders":"National MPS Society; University of Victoria","keywords":"Serpin; Biomarker; Heparin cofactor II; Serine protease; Thrombin; Protease; Proteases; Chemistry; Disease; Pathophysiology; Immunology; Pharmacology; Medicine; Biochemistry; Internal medicine; Enzyme; Platelet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006447918,0.0005843515,0.0005589523,0.002894523,0.0003678633,0.0008328893,0.0005243969,0.00106518,0.001913649],"category_scores_gemma":[0.002727259,0.0003312275,0.000170081,0.0008533912,0.0003946149,0.0004360008,0.0002913367,0.0006998325,0.0004178709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000427587,"about_ca_system_score_gemma":0.000427881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001760177,"about_ca_topic_score_gemma":0.0008960532,"domain_scores_codex":[0.9997132,0.0000661379,0.00005020367,0.00004456409,0.00009064202,0.00003522494],"domain_scores_gemma":[0.9991066,0.0003073563,0.000164263,0.00003873341,0.0001506254,0.0002324056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006203888,0.0003454448,0.5676479,0.0004694305,0.0004016261,0.02494627,0.0006880579,0.0007795052,0.3419833,0.00144233,0.003642644,0.05144954],"study_design_scores_gemma":[0.0002610669,0.002543118,0.7171957,0.0001276947,0.00086208,0.1031213,0.000682312,0.006315493,0.1586066,0.002270531,0.00794224,0.00007173966],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895107,0.005464791,0.001528922,0.0005500046,0.00006198898,0.00003494254,0.0002847317,0.00006258042,0.002501441],"genre_scores_gemma":[0.997894,0.0004456447,0.0009869064,0.00004784386,0.00005374077,0.0000100097,0.0001077863,0.000006795703,0.0004472363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002894523,"threshold_uncertainty_score":0.006401777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02284263876258229,"score_gpt":0.2888983916339858,"score_spread":0.2660557528714035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}