{"id":"W2031052748","doi":"10.1074/jbc.m109.000901","title":"Dual 12/15- and 5-Lipoxygenase Deficiency in Macrophages Alters Arachidonic Acid Metabolism and Attenuates Peritonitis and Atherosclerosis in ApoE Knock-out Mice","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of General Medical Sciences","keywords":"Arachidonic acid; Lipoxygenase; Apolipoprotein E; Knockout mouse; Metabolism; Macrophage; Chemistry; Arachidonate 5-lipoxygenase; Inflammation; Arachidonic acid metabolism; Biochemistry; Internal medicine; Medicine; Enzyme; Disease; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003777605,0.0009293933,0.0006145001,0.0008747948,0.0003091172,0.0005075168,0.0004028885,0.0007301902,0.001351415],"category_scores_gemma":[0.0002051798,0.0005126247,0.0005478865,0.0002300219,0.0006028443,0.0004269942,0.0003571041,0.001302096,0.0005775412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003138884,"about_ca_system_score_gemma":0.0003750451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006947403,"about_ca_topic_score_gemma":0.001007485,"domain_scores_codex":[0.9995596,0.00006459552,0.00007157132,0.00009749791,0.00008085929,0.0001257359],"domain_scores_gemma":[0.9995414,0.00003700896,0.000132959,0.00004536643,0.00003370408,0.0002095537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006684018,0.0001595024,0.0001718898,0.00002789601,0.000008754168,0.00007583334,0.00002537699,0.00003388977,0.99815,0.00008155531,0.00002280506,0.0005741108],"study_design_scores_gemma":[0.0001913338,0.001522067,0.005512536,0.00002272917,0.00007373873,0.0004167245,0.00008260583,0.0009932406,0.9895869,0.0001291568,0.001455119,0.00001385438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99442,0.001074771,0.002825537,0.0001895958,0.00005926394,0.00005320127,0.0004890119,0.0001781794,0.0007104419],"genre_scores_gemma":[0.9874231,0.001217833,0.004516774,0.0001626089,0.0000407916,0.0001669777,0.0005940585,0.000105874,0.005772066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001351415,"threshold_uncertainty_score":0.004520953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01534012234886375,"score_gpt":0.2470455794700777,"score_spread":0.2317054571212139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}