{"id":"W2031075632","doi":"10.1038/nchem.1367","title":"An ultrasensitive universal detector based on neutralizer displacement","year":2012,"lang":"en","type":"article","venue":"Nature Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":200,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Analyte; Chemistry; Biomolecule; Aptamer; Nucleic acid; Small molecule; Molecule; Nanotechnology; Analytical Chemistry (journal); Chromatography; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001064331,0.0002006696,0.0001218851,0.00002036437,0.0000707503,0.00001346039,0.0001230434,0.0004807273,0.00001564081],"category_scores_gemma":[0.00004114757,0.0001733275,0.0001071991,0.00008805485,0.00007266305,0.000005543511,0.0000191018,0.0003008102,0.000002310118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004180322,"about_ca_system_score_gemma":0.00002859084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001683745,"about_ca_topic_score_gemma":0.000001495184,"domain_scores_codex":[0.9990917,0.00003273935,0.0001030725,0.0003223922,0.0001566276,0.00029342],"domain_scores_gemma":[0.9992775,0.00001252633,0.00006366941,0.0004171565,0.00006475898,0.0001643292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000157828,0.0001555116,0.001021799,0.00001052631,0.00002519126,0.000003515925,0.000005777069,0.00001962478,0.9973615,0.000006445362,0.0008475259,0.000384778],"study_design_scores_gemma":[0.0002707049,0.00009709327,0.0007355297,0.00001428265,0.00003350283,0.000007542791,0.00005028116,0.00009701212,0.9891851,0.000002736849,0.009267683,0.000238507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962431,0.0001087865,0.0008009917,0.0001030345,0.00007393676,0.00008188445,0.00005952336,0.00006908822,0.00245963],"genre_scores_gemma":[0.9958559,0.00001385419,0.00208935,0.0007853496,0.0004846022,0.000003371747,0.000453907,0.00002200347,0.0002916109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008420157,"threshold_uncertainty_score":0.7068091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003747764827830952,"score_gpt":0.2660252076669183,"score_spread":0.2622774428390874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}