{"id":"W2031077597","doi":"10.1158/1535-7163.targ-13-c265","title":"Abstract C265: Significant <i>in vivo</i> activity of ENMD-2076, a novel multi-targeted kinase inhibitor, towards xenograft models of human hepatocellular carcinomas .","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Sorafenib; Medicine; Hepatocellular carcinoma; Doxorubicin; Tolerability; In vivo; Cancer; Liver cancer; Pharmacology; Cancer research; Chemotherapy; Oncology; Internal medicine; Adverse effect; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002239162,0.0005946329,0.0003109008,0.0002719417,0.0001428602,0.0001780332,0.0002520281,0.0002600173,0.002384717],"category_scores_gemma":[0.0000824554,0.0001197757,0.0002307552,0.0001720196,0.0001998461,0.0001789385,0.00007993053,0.0007049997,0.0004040324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003460601,"about_ca_system_score_gemma":0.0004666944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001872392,"about_ca_topic_score_gemma":0.001849173,"domain_scores_codex":[0.9999034,0.00002074561,0.000008741491,0.00001697751,0.0000248114,0.00002534969],"domain_scores_gemma":[0.9998987,0.0000273857,0.0000163366,0.000008231324,0.00001367275,0.00003567292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001930556,0.0004156807,0.000167379,0.0001652768,0.0000174585,0.0001044559,0.00001576712,0.0004155226,0.9932472,0.000117538,0.0005386608,0.002864623],"study_design_scores_gemma":[0.0002133464,0.004727625,0.001522671,0.00001012897,0.00003587509,0.0003303039,0.00001538836,0.001038001,0.9897038,0.00001940918,0.002376408,0.000006993379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884456,0.002594582,0.002395856,0.0002178055,0.000138327,0.0001754672,0.001456388,0.0002307901,0.004345029],"genre_scores_gemma":[0.987576,0.001513962,0.003282676,0.0001023266,0.00002671024,0.0001292772,0.003069757,0.00003384215,0.004265398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002384717,"threshold_uncertainty_score":0.007977664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02983269158312039,"score_gpt":0.2663489538847015,"score_spread":0.2365162623015811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}