{"id":"W2031079510","doi":"10.1016/j.nucmedbio.2008.01.004","title":"Use of a column-switching high-performance liquid chromatography method to assess the presence of specific binding of (R)- and (S)-[11C]rolipram and their labeled metabolites to the phosphodiesterase-4 enzyme in rat plasma and tissues","year":2008,"lang":"en","type":"article","venue":"Nuclear Medicine and Biology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Rolipram; Chemistry; Metabolite; Adipose tissue; Phosphodiesterase; In vivo; Enzyme; Skeletal muscle; Biochemistry; Endocrinology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003743129,0.0001198347,0.0003017178,0.00009257369,0.00008482801,0.000005936861,0.00007314203,0.00008345878,0.00000396557],"category_scores_gemma":[0.00007851511,0.00006364338,0.0000156532,0.0001652872,0.0003404181,0.00001130153,0.0001234419,0.00006861019,9.272409e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001840139,"about_ca_system_score_gemma":0.000009796569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00015868,"about_ca_topic_score_gemma":0.00004674213,"domain_scores_codex":[0.9992088,0.0001465416,0.0002545629,0.0002168996,0.00005032823,0.0001228395],"domain_scores_gemma":[0.9994352,0.0001893695,0.0001134498,0.0001539071,0.00005836146,0.00004963799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004596196,0.00001776627,0.0146925,0.00003978291,0.00003958948,4.272638e-7,0.002245323,0.00001115732,0.9769144,0.000149733,0.0002325666,0.005197146],"study_design_scores_gemma":[0.001219116,0.002742902,0.06521025,0.0002031498,0.00003814306,0.0001021167,0.001728795,0.0005878412,0.8740662,0.00002393413,0.05389559,0.0001819455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958184,0.002994678,0.0001568585,0.0007026595,0.0000602865,0.0002425023,0.00001148387,0.000003435953,0.000009633009],"genre_scores_gemma":[0.9934822,0.004990236,0.001169673,0.0002762314,0.00004497965,0.000006628105,0.000007152314,0.000008101679,0.00001478401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1028482,"threshold_uncertainty_score":0.2595302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04634017921468937,"score_gpt":0.2838621022561294,"score_spread":0.23752192304144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}