{"id":"W2031083224","doi":"10.1038/clpt.2013.12","title":"International Transporter Consortium Commentary on Clinically Important Transporter Polymorphisms","year":2013,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"National Institute of General Medical Sciences","keywords":"Clinical pharmacology; Transporter; Pharmacodynamics; Pharmacology; Pharmacogenetics; Pharmacokinetics; Allele; Medicine; Biology; Genetics; Computational biology; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007426069,0.0004253052,0.000878093,0.0001245822,0.0001078982,0.00002018543,0.0004287242,0.0004940048,0.009572286],"category_scores_gemma":[0.000004382829,0.0003312402,0.0007427586,0.0001311155,0.0006807852,0.0001118333,0.00001705195,0.001227133,0.0003573334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005828113,"about_ca_system_score_gemma":0.0001270139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001051149,"about_ca_topic_score_gemma":0.000004352644,"domain_scores_codex":[0.9956506,0.0001416308,0.002429944,0.0007140678,0.0004564126,0.0006073097],"domain_scores_gemma":[0.9981021,0.0003630765,0.0003944005,0.0004414938,0.0001949828,0.0005039694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01057228,0.01183,0.6825389,0.00008750612,0.007489491,0.001628953,0.0006221878,0.00001041193,0.0657979,0.000118817,0.1897679,0.02953565],"study_design_scores_gemma":[0.01942972,0.003710736,0.3484405,0.0001308577,0.004146836,0.00006698373,0.0001709598,0.0006926566,0.007829131,0.000612852,0.6138524,0.000916375],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.784346,0.0002319988,0.0009467056,0.2014397,0.007984171,0.001486462,0.00009147201,0.0002582684,0.003215172],"genre_scores_gemma":[0.60926,0.001651996,0.0009571738,0.385588,0.001312472,0.00007518184,0.0001888413,0.00006096376,0.0009053032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4240845,"threshold_uncertainty_score":0.999914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04790878477863259,"score_gpt":0.3789119958174332,"score_spread":0.3310032110388006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}