{"id":"W2031083224","doi":"10.1038/clpt.2013.12","title":"International Transporter Consortium Commentary on Clinically Important Transporter Polymorphisms","year":2013,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"National Institute of General Medical Sciences","keywords":"Clinical pharmacology; Transporter; Pharmacodynamics; Pharmacology; Pharmacogenetics; Pharmacokinetics; Allele; Medicine; Biology; Genetics; Computational biology; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009988935,0.001691571,0.002776579,0.002213953,0.00381363,0.004780029,0.006850123,0.05554613,0.01538564],"category_scores_gemma":[0.04138801,0.001049799,0.003327269,0.002792378,0.003796534,0.004048187,0.0021803,0.04138225,0.009908298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006888437,"about_ca_system_score_gemma":0.01552803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0147271,"about_ca_topic_score_gemma":0.01833903,"domain_scores_codex":[0.9914737,0.001817433,0.001057796,0.00104603,0.003688237,0.0009168516],"domain_scores_gemma":[0.9699875,0.01447406,0.001733019,0.0007608833,0.01005487,0.00298969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002206246,0.000005022566,0.00002390221,0.00007543495,0.000006517691,0.0001319206,0.00001279691,0.0000173572,0.00002889342,0.0006258571,0.9965547,0.002495419],"study_design_scores_gemma":[0.00007754369,0.00002739086,0.0002819994,0.0008120873,0.00004311818,0.0003740744,0.00005630314,0.00006074893,0.0001042883,0.001576736,0.9965549,0.00003073572],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0001031534,0.008326376,0.0002180987,0.7237629,0.2622405,0.00004123899,0.0003269672,0.00007553985,0.004905121],"genre_scores_gemma":[0.001079631,0.005109129,0.0002737498,0.8327217,0.15198,0.0001136668,0.0001670133,0.00006794505,0.00848729],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.05554613,"threshold_uncertainty_score":0.05282718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04790878477863259,"score_gpt":0.3789119958174332,"score_spread":0.3310032110388006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}