{"id":"W2031096206","doi":"10.1016/j.bpj.2011.11.2365","title":"Effects of Tryptophan Substitutions for Highly-Conserved Phenylalanines in the Skeletal Muscle L-Type Calcium Channel","year":2012,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Depolarization; Shaker; Biophysics; Chemistry; Gating; Skeletal muscle; Voltage clamp; Coupling (piping); Membrane potential; Biochemistry; Biology; Anatomy; Materials science; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007720139,0.00117841,0.0008185668,0.0003358278,0.0008334311,0.0005726888,0.001048321,0.001649446,0.003493259],"category_scores_gemma":[0.00115015,0.0005110857,0.0009092132,0.0003027655,0.001454906,0.0005635241,0.0006898781,0.001466252,0.0007452413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008159796,"about_ca_system_score_gemma":0.0007962105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003580353,"about_ca_topic_score_gemma":0.003982187,"domain_scores_codex":[0.9992142,0.000285172,0.0001414193,0.0001149605,0.0001117285,0.0001325917],"domain_scores_gemma":[0.9985097,0.0006201108,0.0003686034,0.0001206306,0.0001120738,0.0002687351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006028424,0.0004904151,0.0009455455,0.0001401877,0.0002026293,0.002596437,0.0001256451,0.001605975,0.9835186,0.0007552589,0.0001850593,0.003405769],"study_design_scores_gemma":[0.001200059,0.003254307,0.01174715,0.00006850834,0.0005424942,0.003209457,0.0003224025,0.01257104,0.9643424,0.0005413265,0.00205554,0.000145319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977468,0.0003330891,0.001022285,0.0001386942,0.00007048124,0.0000317477,0.0001281961,0.00004886602,0.0004797759],"genre_scores_gemma":[0.9984666,0.000161757,0.0006349039,0.00009123293,0.00001865636,0.00001415104,0.00007138849,0.00004444591,0.0004968491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003580353,"threshold_uncertainty_score":0.01168609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02058313016405457,"score_gpt":0.268096044035216,"score_spread":0.2475129138711614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}