{"id":"W2031097791","doi":"10.1016/j.tiv.2011.01.014","title":"The effect of Nrf2 knockout on the constitutive expression of drug metabolizing enzymes and transporters in C57Bl/6 mice livers","year":2011,"lang":"en","type":"article","venue":"Toxicology in Vitro","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Pregnane X receptor; Constitutive androstane receptor; Aryl hydrocarbon receptor; Knockout mouse; Multidrug resistance-associated protein 2; Transcription factor; Gene knockout; Nuclear receptor; Chemistry; Cytochrome P450; Glutathione; Biology; Molecular biology; Receptor; Biochemistry; Enzyme; ATP-binding cassette transporter; Transporter; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003649966,0.0008603504,0.0006025626,0.0006691492,0.0002760023,0.0004655719,0.0003868505,0.0008651418,0.003397712],"category_scores_gemma":[0.0002489122,0.0005025261,0.0005333404,0.0002943688,0.0008200709,0.000632189,0.0002670453,0.001644299,0.0006383017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004029186,"about_ca_system_score_gemma":0.0003924379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0014985,"about_ca_topic_score_gemma":0.002361059,"domain_scores_codex":[0.9996918,0.00004676612,0.00004053397,0.00009046357,0.00005337569,0.00007701479],"domain_scores_gemma":[0.9992099,0.0001137708,0.0002070545,0.00009872003,0.00006028819,0.0003103046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001390713,0.0001266126,0.0001524142,0.00004657215,0.00001228738,0.00009458716,0.00002185144,0.00007301382,0.9973604,0.0001448286,0.00007269865,0.0005040549],"study_design_scores_gemma":[0.00008446102,0.0009077051,0.003356143,0.00001100746,0.00004762191,0.0001890812,0.0000584017,0.0004065545,0.9938654,0.0001224013,0.0009377669,0.00001337174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933578,0.001228623,0.001444381,0.0004671231,0.000115125,0.00003790969,0.00172395,0.0002114951,0.001413555],"genre_scores_gemma":[0.9844528,0.00104066,0.002291619,0.0002238305,0.00003270282,0.00009983432,0.001379865,0.0001073017,0.01037127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003397712,"threshold_uncertainty_score":0.01136643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009468693985252097,"score_gpt":0.2233659298957983,"score_spread":0.2138972359105462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}