{"id":"W2031162547","doi":"10.1016/s0165-2478(02)00185-2","title":"Prostaglandin E2 and cAMP promote B lymphocyte class switching to IgG1","year":2002,"lang":"en","type":"article","venue":"Immunology Letters","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; U.S. Public Health Service","keywords":"Immunoglobulin class switching; Isotype; Immune system; Biology; Prostaglandin E; Germline; Immunology; Antibody; B cell; Cell biology; Intracellular; Lymphocyte; Endocrinology; Monoclonal antibody; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002451912,0.0004887477,0.0006226033,0.0003794035,0.0005213915,0.00006564533,0.0005191338,0.00058135,0.0005871981],"category_scores_gemma":[0.0000909099,0.0004426716,0.0001220087,0.0002726007,0.0005364003,0.0001975525,0.0003772305,0.0007629264,0.002783124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001518164,"about_ca_system_score_gemma":0.00002557817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001440561,"about_ca_topic_score_gemma":0.00003197724,"domain_scores_codex":[0.9971838,0.0003485865,0.0004318757,0.0008266807,0.00005343785,0.001155624],"domain_scores_gemma":[0.9988685,0.0001538777,0.0001827965,0.0006863616,0.00005163148,0.00005685456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000187059,0.0001168302,0.001362103,0.00001530375,0.000418747,0.00007444231,0.001922874,0.000002068052,0.9717008,0.0002436451,0.008492568,0.01546358],"study_design_scores_gemma":[0.005821231,0.0008181921,0.00258538,0.0000785302,0.0001114921,0.00188063,0.000435802,0.00002305959,0.5169697,0.0000882151,0.4701934,0.0009943899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9644635,0.008242964,0.0002405285,0.02380968,0.001739199,0.0006180084,0.00001844023,0.0002849107,0.0005827997],"genre_scores_gemma":[0.9891669,0.0003637281,0.0002318822,0.005026701,0.00006993768,0.0001030189,0.00004334364,0.00005840032,0.004936088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4617008,"threshold_uncertainty_score":0.9998025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01010786624366393,"score_gpt":0.2031062920083654,"score_spread":0.1929984257647015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}