{"id":"W2031165260","doi":"10.1158/0008-5472.sabcs10-s1-4","title":"Abstract S1-4: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of AMG 479 With Exemestane (E) or Fulvestrant (F) in Postmenopausal Women With Hormone-Receptor Positive (HR+) Metastatic (M) or Locally Advanced (LA) Breast Cancer (BC)","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Fulvestrant; Placebo; Internal medicine; Exemestane; Metastatic breast cancer; Clinical endpoint; Breast cancer; Oncology; Cancer; Estrogen receptor; Clinical trial; Tamoxifen; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001915479,0.002715173,0.003894013,0.0009626829,0.0007500194,0.001117274,0.001531524,0.003156868,0.01666723],"category_scores_gemma":[0.001639937,0.001339214,0.002016163,0.0004780199,0.001858635,0.001387093,0.0004560822,0.00357819,0.00247871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008379903,"about_ca_system_score_gemma":0.002580892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009152979,"about_ca_topic_score_gemma":0.001954421,"domain_scores_codex":[0.9992595,0.000370702,0.00005600923,0.0001216369,0.00005153851,0.000140504],"domain_scores_gemma":[0.9990362,0.0002378484,0.0001668934,0.00008096723,0.00007227423,0.0004058667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9785324,0.01088348,0.0001404039,0.0003325853,0.0002129161,0.00002711609,0.00002020783,0.0001463009,0.004157521,0.00006234217,0.0004927368,0.004991966],"study_design_scores_gemma":[0.9414246,0.05734739,0.0003028381,0.00001097732,0.0001019857,0.000009185211,0.000005548737,0.0001308751,0.0003624964,0.0000475548,0.0002499486,0.000006643159],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9606124,0.00252509,0.001250858,0.001099219,0.0009102343,0.02663305,0.003381382,0.0004510346,0.00313674],"genre_scores_gemma":[0.9345173,0.002715847,0.004819859,0.002339843,0.001114332,0.03940863,0.002972764,0.00008448828,0.01202691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01666723,"threshold_uncertainty_score":0.0557574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03862540612205098,"score_gpt":0.38073727639355,"score_spread":0.342111870271499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}