{"id":"W2031187294","doi":"10.1002/adsc.200800667","title":"Palladium‐Catalyzed <i>N</i>‐Demethylation/<i>N</i>‐Acylation of Some Morphine and Tropane Alkaloids","year":2008,"lang":"en","type":"article","venue":"Advanced Synthesis & Catalysis","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada; Brock University","keywords":"Chemistry; Acylation; Demethylation; Tropane; Palladium; Hydrocodone; Catalysis; Morphine; Medicinal chemistry; Stereochemistry; Organic chemistry; Opioid; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000226399,0.0004460783,0.0009356803,0.0001804755,0.0002517979,0.00002182121,0.0003624859,0.0002147118,0.0007875531],"category_scores_gemma":[0.0009218248,0.0004240543,0.0003524842,0.0004722844,0.0003668198,0.0005587141,0.0001380701,0.0002082788,0.00003217806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009673375,"about_ca_system_score_gemma":0.00004831688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001491738,"about_ca_topic_score_gemma":0.00001379132,"domain_scores_codex":[0.9972562,0.00004099955,0.0009142795,0.000750547,0.0005688885,0.0004691116],"domain_scores_gemma":[0.997221,0.001030073,0.0004911625,0.0008624594,0.0001510543,0.0002442707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001087681,0.0001785771,0.004293303,0.0001339747,0.0002068092,0.00001158012,0.0001555836,0.0001075488,0.9572751,0.0001157834,0.00004291531,0.03737004],"study_design_scores_gemma":[0.0006150671,0.00001287563,0.002253715,0.00009345699,0.0003076575,0.0000297709,0.00009169139,0.000304491,0.9932652,0.0006071526,0.001934378,0.0004845311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942792,0.002814229,0.0002246773,0.00028155,0.00003773821,0.0001060439,0.0001062289,0.0001461359,0.002004176],"genre_scores_gemma":[0.9941912,0.002009701,0.002793928,0.00004880578,0.0001671607,0.00009306361,0.000186087,0.00007159208,0.0004385222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03688551,"threshold_uncertainty_score":0.9998211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131886146783648,"score_gpt":0.2135365157896045,"score_spread":0.2022176543217681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}