{"id":"W2031188341","doi":"10.1097/00006454-200008000-00025","title":"LIMITATIONS OF SINGLE POINT PHARMACODYNAMIC ANALYSIS","year":2000,"lang":"en","type":"letter","venue":"The Pediatric Infectious Disease Journal","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Studies","funders":"","keywords":"Pharmacodynamics; Population; Medicine; Pharmacokinetics; Dosing; Streptococcus pneumoniae; Haemophilus influenzae; Statistics; Drug; Pharmacology; Intensive care medicine; Mathematics; Antibiotics; Biology; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1360647,0.001555909,0.003572152,0.003318279,0.0007770167,0.004909094,0.006083407,0.003870036,0.006420025],"category_scores_gemma":[0.4256058,0.0008785622,0.003209615,0.004474999,0.002041007,0.004624316,0.002988289,0.009910062,0.002635614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001881442,"about_ca_system_score_gemma":0.003371486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003046095,"about_ca_topic_score_gemma":0.002014,"domain_scores_codex":[0.8399991,0.1122498,0.0119269,0.006172366,0.02898697,0.0006648618],"domain_scores_gemma":[0.3764598,0.551009,0.01681312,0.01722168,0.03721661,0.001279845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001466366,0.0002050897,0.0146005,0.005471596,0.003573316,0.000582871,0.00117248,0.01418363,0.000319112,0.03108632,0.2798729,0.6474659],"study_design_scores_gemma":[0.0009337652,0.001298927,0.02103272,0.01046541,0.002854829,0.003661711,0.001262008,0.1225021,0.001909453,0.2472876,0.5861117,0.0006799175],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"commentary","genre_scores_codex":[0.01306638,0.1035904,0.5145866,0.2781468,0.05354109,0.001724687,0.009361727,0.002783215,0.02319917],"genre_scores_gemma":[0.3781637,0.05981674,0.2647661,0.1842542,0.09553101,0.005430205,0.002895815,0.002033219,0.007109078],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.1360647,"threshold_uncertainty_score":0.7195877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03142590812817479,"score_gpt":0.2666997334038345,"score_spread":0.2352738252756597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}