{"id":"W2031216928","doi":"10.1016/j.peptides.2005.03.022","title":"Development of an efficient strategy for the synthesis of the ETB receptor antagonist BQ-788 and some related analogues","year":2005,"lang":"en","type":"article","venue":"Peptides","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Université de Sherbrooke","keywords":"Chemistry; Moiety; Norleucine; Antagonist; Sodium iodide; Triphosgene; Urea; Yield (engineering); Stereochemistry; Indole test; Combinatorial chemistry; Amino acid; Receptor; Organic chemistry; Biochemistry; Methionine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002170886,0.0000830365,0.0001019657,0.0000140515,0.0001190964,0.000008985357,0.0001463423,0.00005831886,0.000008194103],"category_scores_gemma":[0.00005717411,0.00004826405,0.00005053394,0.00004279699,0.0001124349,0.000002812909,0.00005101747,0.00003384807,5.193367e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005194312,"about_ca_system_score_gemma":0.00005805664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001247983,"about_ca_topic_score_gemma":0.00001559731,"domain_scores_codex":[0.9994336,0.00002867765,0.0002171002,0.0001396492,0.00007381288,0.0001071365],"domain_scores_gemma":[0.999589,0.00005337799,0.0001104529,0.0001744196,0.00004919585,0.00002358573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001120076,0.0001348376,0.0008158626,0.00006260117,0.0001733077,1.507863e-7,0.0005959668,0.005413577,0.9723915,0.0005511239,0.001034154,0.01871484],"study_design_scores_gemma":[0.000181881,0.00006834168,0.003139809,0.00002840643,0.0000347384,0.000002444981,0.0005035761,0.000677403,0.9877741,0.00002851446,0.007473093,0.00008766271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974747,0.001945412,0.0001179181,0.0001784306,0.00003353761,0.0001377381,0.00002263081,0.000003470891,0.00008618517],"genre_scores_gemma":[0.9972139,0.00009743754,0.002396958,0.00003615833,0.00008504724,0.00001685341,0.00001832227,0.000008988322,0.0001263252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01862718,"threshold_uncertainty_score":0.1968151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01613915447011999,"score_gpt":0.254523729313393,"score_spread":0.238384574843273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}