{"id":"W2031220986","doi":"10.2174/187152011797655050","title":"Hypoxia-Inducible Factors and Sphingosine 1-Phosphate Signaling","year":2011,"lang":"en","type":"review","venue":"Anti-Cancer Agents in Medicinal Chemistry","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; Université de Toulouse; Institut National Du Cancer; Association pour la Recherche sur les Tumeurs de la Prostate; Ligue Contre le Cancer; Association pour la Recherche sur le Cancer","keywords":"Angiogenesis; Sphingosine-1-phosphate; Sphingosine kinase 1; Sphingosine; Cancer research; Hypoxia (environmental); Hypoxia-inducible factors; PTEN; Sphingosine kinase; Transcription factor; Biology; Signal transduction; Regulator; Kinase; Sphingolipid; Cell biology; Chemistry; PI3K/AKT/mTOR pathway; Biochemistry; Receptor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001780186,0.0006854649,0.0007326706,0.001048563,0.0002523147,0.0006127137,0.0004938184,0.0007343255,0.002741115],"category_scores_gemma":[0.0001715624,0.0001762003,0.0002171167,0.001165035,0.0002656679,0.0007696197,0.000422879,0.001165875,0.002873597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005504783,"about_ca_system_score_gemma":0.0006966481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007603274,"about_ca_topic_score_gemma":0.001224065,"domain_scores_codex":[0.999931,0.00000891879,0.000007266972,0.0000119731,0.00003005734,0.00001081391],"domain_scores_gemma":[0.9999402,0.00001365887,0.00001192185,0.000001872838,0.0000198864,0.00001242753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001002312,0.00009406114,0.0001713583,0.00763962,0.00004892465,0.0003693099,0.00005900984,0.0003886861,0.01345886,0.005296278,0.02886919,0.9435045],"study_design_scores_gemma":[0.00001597771,0.00007083068,0.0007325281,0.0006692836,0.00003131637,0.001197714,0.00003636779,0.00008441205,0.002282671,0.001992466,0.9928745,0.00001205486],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003211534,0.9968291,0.0002436133,0.0003026824,0.0001955383,0.000006604612,0.0000258809,0.00001191854,0.002063473],"genre_scores_gemma":[0.001770747,0.9956453,0.0002691677,0.0001507984,0.0001539928,0.000009609599,0.00005573346,0.00000119242,0.001943455],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002741115,"threshold_uncertainty_score":0.009169996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06283560590419697,"score_gpt":0.3386893520133181,"score_spread":0.2758537461091211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}