{"id":"W2031245658","doi":"10.2353/ajpath.2009.080521","title":"Proteome-Wide Identification of Novel Binding Partners to the Oncogenic Fusion Gene Protein, NPM-ALK, using Tandem Affinity Purification and Mass Spectrometry","year":2009,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"University of California, Irvine; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Alberta Cancer Foundation","keywords":"Tandem affinity purification; Anaplastic lymphoma kinase; Nucleophosmin; Fusion protein; Carcinogenesis; Biology; Fusion gene; Proteome; Molecular biology; Anaplastic large-cell lymphoma; Gene; Cancer research; Biochemistry; Lymphoma; Affinity chromatography; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002779517,0.0003973991,0.0004423005,0.0005289238,0.0005892939,0.0005573622,0.0003074038,0.0004107947,0.0009444144],"category_scores_gemma":[0.0003396735,0.0002022762,0.0003103121,0.0004574624,0.0001815015,0.0002360494,0.000315807,0.0005637879,0.0006689111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004824978,"about_ca_system_score_gemma":0.0003148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001630534,"about_ca_topic_score_gemma":0.003785745,"domain_scores_codex":[0.9997552,0.00002215908,0.00001189162,0.00006264116,0.0001135905,0.00003455074],"domain_scores_gemma":[0.9998904,0.00002057083,0.00002046696,0.000009347716,0.00003599413,0.00002315818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001280362,0.00003434522,0.001637841,0.00004797851,0.00003809897,0.00008175137,0.00002659615,0.00007239926,0.9951616,0.00009328602,0.0004193004,0.002258744],"study_design_scores_gemma":[0.00008653414,0.0002316037,0.1715337,0.00001921711,0.0002356355,0.003601618,0.0002438001,0.01163837,0.790898,0.0006255494,0.02084437,0.00004160781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815537,0.003834557,0.009048434,0.0006653825,0.0000765786,0.00005839537,0.002602517,0.0002283273,0.001932141],"genre_scores_gemma":[0.9715447,0.001808507,0.01279001,0.000432305,0.00005640355,0.0000642458,0.008428489,0.00006874869,0.004806603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001630534,"threshold_uncertainty_score":0.003500819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02877001839976207,"score_gpt":0.3144124556590679,"score_spread":0.2856424372593058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}