{"id":"W2031245658","doi":"10.2353/ajpath.2009.080521","title":"Proteome-Wide Identification of Novel Binding Partners to the Oncogenic Fusion Gene Protein, NPM-ALK, using Tandem Affinity Purification and Mass Spectrometry","year":2009,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"University of California, Irvine; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Alberta Cancer Foundation","keywords":"Tandem affinity purification; Anaplastic lymphoma kinase; Nucleophosmin; Fusion protein; Carcinogenesis; Biology; Fusion gene; Proteome; Molecular biology; Anaplastic large-cell lymphoma; Gene; Cancer research; Biochemistry; Lymphoma; Affinity chromatography; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007214585,0.0001218866,0.0003948774,0.0002750297,0.0000878331,0.00001534416,0.00009860486,0.00004361498,0.00000546661],"category_scores_gemma":[0.0002719203,0.00008193564,0.00009409946,0.0004796862,0.0001342811,0.00006738251,0.00001794309,0.0001259024,0.000002370397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001935596,"about_ca_system_score_gemma":0.0001337514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001026183,"about_ca_topic_score_gemma":0.000001069902,"domain_scores_codex":[0.9986975,0.0001174233,0.0005703659,0.0001822338,0.0002507216,0.0001817852],"domain_scores_gemma":[0.998453,0.00006637924,0.0009455546,0.0002228486,0.0001925995,0.0001196002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001545264,0.0003330419,0.0213946,0.000006748223,0.00004983699,0.0000786663,0.000349857,0.0000383088,0.9627796,0.00004284467,0.00001244484,0.01475951],"study_design_scores_gemma":[0.00191086,0.003810921,0.4614702,0.000124753,0.0003041601,0.001956082,0.0007910248,0.0001451894,0.5291414,0.0001144677,0.0001039611,0.0001270168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829979,0.0002386136,0.01272093,0.003389697,0.00005583447,0.0005560422,0.000005547522,0.000006328521,0.00002910424],"genre_scores_gemma":[0.971353,0.0001134501,0.02815728,0.0002349622,0.0001034086,0.00001195666,0.000003440256,0.000009290326,0.00001318792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4400756,"threshold_uncertainty_score":0.3341238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02877001839976207,"score_gpt":0.3144124556590679,"score_spread":0.2856424372593058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}