{"id":"W2031253712","doi":"10.1128/jvi.79.13.8014-8023.2005","title":"Pyrrolidine Dithiocarbamate Reduces Coxsackievirus B3 Replication through Inhibition of the Ubiquitin-Proteasome Pathway","year":2005,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Michael Smith Health Research BC; Canadian Institutes of Health Research; Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"Pyrrolidine dithiocarbamate; Coxsackievirus; Proteasome; Biology; Viral replication; Ubiquitin; MG132; Protein degradation; Virology; Viral Myocarditis; Proteasome inhibitor; Virus; NF-κB; Biochemistry; Signal transduction; Enterovirus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007252574,0.00009622642,0.0003392299,0.0001259618,0.0000812158,0.000006867361,0.0001225906,0.0001636396,0.0001190809],"category_scores_gemma":[0.0003938682,0.00005966035,0.0001763018,0.0002246314,0.0002993392,0.0002019521,0.00006125878,0.000569084,0.00002276857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007457488,"about_ca_system_score_gemma":0.0001394319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001876138,"about_ca_topic_score_gemma":0.000003986663,"domain_scores_codex":[0.9986548,0.0001999606,0.0006044526,0.0001346288,0.0002153203,0.0001908163],"domain_scores_gemma":[0.9985968,0.00005000123,0.0005872484,0.0003690403,0.0003540438,0.00004281459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004548834,0.0002718945,0.0009541745,0.00001950724,0.00009426992,0.0000116882,0.0001700356,0.00003107733,0.9849502,0.0006871403,0.0008662932,0.01148878],"study_design_scores_gemma":[0.001560785,0.002070567,0.0293285,0.0001170097,0.00008049764,0.001544737,0.00007650701,0.00008061729,0.9433802,0.0008287391,0.02086854,0.00006333867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766756,0.001324307,0.00009177563,0.01980486,0.000199249,0.0002245586,0.00000439934,0.000009647022,0.001665578],"genre_scores_gemma":[0.9973707,0.0008185901,0.0002900615,0.0007077777,0.0004147659,0.000009592043,0.00000246511,0.00001227562,0.0003737625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04157008,"threshold_uncertainty_score":0.2472418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03194779653836479,"score_gpt":0.329092905999064,"score_spread":0.2971451094606993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}