{"id":"W2031253712","doi":"10.1128/jvi.79.13.8014-8023.2005","title":"Pyrrolidine Dithiocarbamate Reduces Coxsackievirus B3 Replication through Inhibition of the Ubiquitin-Proteasome Pathway","year":2005,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Michael Smith Health Research BC; Canadian Institutes of Health Research; Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"Pyrrolidine dithiocarbamate; Coxsackievirus; Proteasome; Biology; Viral replication; Ubiquitin; MG132; Protein degradation; Virology; Viral Myocarditis; Proteasome inhibitor; Virus; NF-κB; Biochemistry; Signal transduction; Enterovirus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001182589,0.0003196824,0.0002585213,0.0001632516,0.0001670645,0.000187008,0.000189296,0.0002950342,0.001151314],"category_scores_gemma":[0.0001181352,0.0001134267,0.0002169127,0.0001028458,0.0001559562,0.0001411878,0.0001231523,0.0005230178,0.0001568758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000239463,"about_ca_system_score_gemma":0.0002541382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001335284,"about_ca_topic_score_gemma":0.001835935,"domain_scores_codex":[0.9999038,0.00001605545,0.000008196351,0.00001538154,0.00002423795,0.00003237432],"domain_scores_gemma":[0.999927,0.00001741737,0.00001753366,0.000007891082,0.00001237996,0.00001770725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001788391,0.00005982754,0.00005408562,0.00005704719,0.000007238025,0.00002100016,0.000008662996,0.00003737619,0.9983882,0.00003353698,0.00005446077,0.001099724],"study_design_scores_gemma":[0.00002633777,0.0004563027,0.001315123,0.000003666046,0.00001164565,0.00004502715,0.000007326293,0.0004628923,0.9965922,0.00001653462,0.001060247,0.000002604643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902243,0.005335981,0.001703393,0.0001751284,0.00007826724,0.00004639909,0.0002042398,0.0001453244,0.00208697],"genre_scores_gemma":[0.9946961,0.001648718,0.001323569,0.0000666168,0.00001693028,0.00004021473,0.0002376253,0.00001673478,0.001953418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001335284,"threshold_uncertainty_score":0.003851533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03194779653836479,"score_gpt":0.329092905999064,"score_spread":0.2971451094606993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}