{"id":"W2031256158","doi":"10.1007/s10637-014-0187-1","title":"In vitro evaluation of a tetrahydroisoquinoline derivative as a steroid sulfatase inhibitor and a selective estrogen receptor modulator","year":2014,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Centre Hospitalier Universitaire de Québec","keywords":"Selective estrogen receptor modulator; Steroid sulfatase; Estrogen receptor; Chemistry; Estrogen; Pharmacology; Raloxifene; Cell growth; Antiestrogen; Alkaline phosphatase; Estrogen receptor alpha; Steroid; Endocrinology; Internal medicine; Biochemistry; Hormone; Biology; Medicine; Cancer; Breast cancer; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004572322,0.0002800593,0.0003813906,0.0002052941,0.0002237656,0.0001652492,0.0004304611,0.0002358444,0.001436688],"category_scores_gemma":[0.0002119183,0.0001561746,0.0002675478,0.0001867163,0.000179271,0.0001522355,0.0001025789,0.0002773587,0.0002624427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002112507,"about_ca_system_score_gemma":0.0002925408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001900459,"about_ca_topic_score_gemma":0.003565822,"domain_scores_codex":[0.9998294,0.00007034837,0.00001325518,0.00001977976,0.00003737236,0.00002982351],"domain_scores_gemma":[0.9998837,0.00005305785,0.0000142454,0.000009384122,0.0000233986,0.00001625405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001280869,0.0003162691,0.0001943656,0.0001346751,0.00002812203,0.000157754,0.00005300673,0.0005900329,0.9925332,0.0001632622,0.0001408825,0.004407507],"study_design_scores_gemma":[0.0002328204,0.008282329,0.001382553,0.00001016344,0.0001131608,0.0002910449,0.00004899705,0.001432087,0.9824495,0.00003649004,0.005710184,0.00001068922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792671,0.01336518,0.003549776,0.0001464334,0.0001151282,0.0001090378,0.0003581658,0.00007443009,0.003014757],"genre_scores_gemma":[0.9861094,0.006715238,0.002820774,0.00005605189,0.00006122471,0.0000551722,0.0006107783,0.00001418886,0.00355712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001900459,"threshold_uncertainty_score":0.004806161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007794038978604045,"score_gpt":0.2511937937726388,"score_spread":0.2433997547940348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}