{"id":"W2031270991","doi":"10.1038/clpt.2011.2","title":"Use of Transgenic and Knockout Mouse Models to Assess Solute Carrier Transporter Function","year":2011,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Transporter; Solute carrier family; Function (biology); In vivo; Pharmacology; Drug; Endogeny; Knockout mouse; Xenobiotic; Genetically modified mouse; Transgene; Computational biology; Biology; Chemistry; Cell biology; Biochemistry; Genetics; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003518981,0.002138058,0.001157179,0.005020954,0.001054417,0.001743247,0.001432498,0.003059034,0.008436403],"category_scores_gemma":[0.002107424,0.001049595,0.00129886,0.001301395,0.001795272,0.002260662,0.001095416,0.005529677,0.002256687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001014444,"about_ca_system_score_gemma":0.0009041399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001723383,"about_ca_topic_score_gemma":0.003598841,"domain_scores_codex":[0.9973954,0.000437636,0.0004895453,0.0006574831,0.0007107314,0.0003092417],"domain_scores_gemma":[0.9965425,0.0009257468,0.001069663,0.0003797294,0.0005339514,0.0005483367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005790288,0.0008278664,0.001046157,0.0002773447,0.0001040407,0.0005980305,0.0001677514,0.0004348725,0.9802899,0.00468489,0.002008839,0.008981277],"study_design_scores_gemma":[0.0007429141,0.003592443,0.007409599,0.0003081411,0.0006665345,0.005540936,0.0003397378,0.005775019,0.9290636,0.003466942,0.04290228,0.0001919566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6278737,0.01130936,0.2984602,0.005986528,0.003452227,0.004059467,0.01928644,0.005620306,0.02395173],"genre_scores_gemma":[0.6042131,0.02216375,0.2732128,0.003340964,0.0005823977,0.00893417,0.02572131,0.002988317,0.05884317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008436403,"threshold_uncertainty_score":0.02822262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4428199905092029,"score_gpt":0.4043460352897484,"score_spread":0.03847395521945451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}