{"id":"W2031297530","doi":"10.1021/ja8011066","title":"Immobilized DNA Switches as Electronic Sensors for Picomolar Detection of Plasma Proteins","year":2008,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canadian Institute for Advanced Research","keywords":"Chemistry; Aptamer; Analyte; Biosensor; DNA; Detection limit; Macromolecule; Nanotechnology; Biophysics; Chromatography; Biochemistry; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003760165,0.0004044119,0.0002303411,0.0003607425,0.0001238977,0.0005337646,0.0006227369,0.000575237,0.0008347335],"category_scores_gemma":[0.0005190633,0.0002949256,0.0002218856,0.0002896465,0.0004807477,0.0004604384,0.0002738023,0.0007322748,0.0005432154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003605608,"about_ca_system_score_gemma":0.0002221446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000131917,"about_ca_topic_score_gemma":0.0002642887,"domain_scores_codex":[0.9996252,0.00008986211,0.00001972947,0.00007308309,0.0001631319,0.00002890347],"domain_scores_gemma":[0.999827,0.00009421696,0.00002641885,0.00001136991,0.00002247563,0.00001850847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005805016,0.00002850167,0.00008855282,0.0001124022,0.000008174327,0.00005535219,0.00003197764,0.000727287,0.9874921,0.002004117,0.0001089474,0.009284717],"study_design_scores_gemma":[0.00002163665,0.0001953137,0.0001516853,0.000008644666,0.00001221517,0.0001307913,0.00001340702,0.003137797,0.9882849,0.0006140693,0.007417475,0.00001193145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6112396,0.03882238,0.3330719,0.001202831,0.001133582,0.0004426556,0.0005997304,0.001857053,0.01163025],"genre_scores_gemma":[0.749256,0.01448406,0.2215455,0.0009517289,0.0002331682,0.0003176332,0.0005083209,0.0001189127,0.01258464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008347335,"threshold_uncertainty_score":0.002792478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006558861318776372,"score_gpt":0.2497118118938064,"score_spread":0.2431529505750301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}