{"id":"W2031297530","doi":"10.1021/ja8011066","title":"Immobilized DNA Switches as Electronic Sensors for Picomolar Detection of Plasma Proteins","year":2008,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canadian Institute for Advanced Research","keywords":"Chemistry; Aptamer; Analyte; Biosensor; DNA; Detection limit; Macromolecule; Nanotechnology; Biophysics; Chromatography; Biochemistry; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001887338,0.0001173914,0.0002831818,0.00001278457,0.00008151631,0.000004408564,0.0002023623,0.00008262952,3.583463e-7],"category_scores_gemma":[0.000188485,0.00007619972,0.0007635759,0.0001641655,0.000369348,0.000003752031,0.00005016584,0.0001845035,1.096921e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005830065,"about_ca_system_score_gemma":0.0001025748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009936078,"about_ca_topic_score_gemma":0.000001103532,"domain_scores_codex":[0.999162,0.00003335208,0.0003068135,0.0001396791,0.0001677493,0.0001904471],"domain_scores_gemma":[0.9988447,0.00002712958,0.0006964047,0.0001922501,0.0001962719,0.00004326254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002776909,0.00006908571,0.0001416532,0.000007410704,0.0001692604,2.321489e-7,0.00002835749,0.000005391394,0.9979813,0.000001214569,0.0002009493,0.001117487],"study_design_scores_gemma":[0.0003617299,0.0005879686,0.00008673195,0.00001154664,0.00006634181,0.0001513189,0.0001167309,0.00005965115,0.9956915,0.0001201066,0.002650849,0.00009556473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997752,0.00008250008,0.001763,0.0002338351,0.0000198879,0.0001296948,0.000003735528,0.000006970315,0.000008396004],"genre_scores_gemma":[0.9935241,0.0003198559,0.005768944,0.0001509047,0.0001578764,0.000004124391,0.000001946314,0.00001387592,0.00005835751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004227865,"threshold_uncertainty_score":0.3107334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006558861318776372,"score_gpt":0.2497118118938064,"score_spread":0.2431529505750301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}