{"id":"W2031330547","doi":"10.1006/bbrc.2002.6516","title":"The CrkL Adapter Protein Is Required for Type I Interferon-Dependent Gene Transcription and Activation of the Small G-Protein Rap1","year":2002,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto","funders":"Turun Yliopistollinen Keskussairaala; University of California, Irvine; University of California, San Diego; National Cancer Institute; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"Rap1; Signal transducing adaptor protein; Cell biology; Chemistry; SH3 domain; GTPase; Small GTPase; Biology; Signal transduction; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001881826,0.0004210193,0.0003256332,0.0003124838,0.0004981183,0.0007265509,0.0003412692,0.0004318451,0.001875129],"category_scores_gemma":[0.0004887955,0.0003538391,0.00028852,0.000169368,0.0003008001,0.0003684159,0.0005812227,0.001011247,0.001617787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008640066,"about_ca_system_score_gemma":0.0003232808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006570369,"about_ca_topic_score_gemma":0.001121455,"domain_scores_codex":[0.9996507,0.00004569167,0.0000318101,0.00007873729,0.00008373727,0.0001092913],"domain_scores_gemma":[0.9995335,0.00005991458,0.0001530715,0.00007600989,0.00004842032,0.0001290199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002086836,0.00001503425,0.0004662968,0.00003028279,0.000005298627,0.000153744,0.00001397913,0.00005670112,0.9973362,0.0002208247,0.0001488628,0.001344013],"study_design_scores_gemma":[0.00005804675,0.0001012572,0.0250528,0.00001554465,0.00002625423,0.001618166,0.00009019561,0.0019759,0.9645401,0.000259874,0.006247969,0.00001401094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915176,0.001608712,0.003521781,0.0003209776,0.00006706997,0.00001580553,0.0005164427,0.0002473076,0.002184324],"genre_scores_gemma":[0.9940675,0.0003045593,0.00208509,0.00009484128,0.0000193659,0.00001668322,0.001334425,0.00007438279,0.002003152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001875129,"threshold_uncertainty_score":0.006272972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2392003481929207,"score_gpt":0.3752976364619222,"score_spread":0.1360972882690014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}