{"id":"W2031348353","doi":"10.1016/j.taap.2006.07.007","title":"Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: Hormone production","year":2006,"lang":"en","type":"article","venue":"Toxicology and Applied Pharmacology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":194,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"U.S. Environmental Protection Agency","keywords":"Internal medicine; Endocrinology; Aminoglutethimide; Pregnenolone; Testosterone (patch); Hormone; Forskolin; Adrenocortical carcinoma; Ketoconazole; In vitro; Cell culture; Chemistry; Biology; Vinclozolin; Steroid hormone; Stimulation; Steroid; Aromatase; Medicine; Biochemistry; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005951875,0.000836262,0.0006983112,0.001033357,0.0004402555,0.0004562153,0.0006204101,0.0004194792,0.00438871],"category_scores_gemma":[0.0003224331,0.0004079475,0.0006447106,0.000667939,0.0002876291,0.000381413,0.0004447277,0.001230026,0.004290927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004007432,"about_ca_system_score_gemma":0.000400125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005366869,"about_ca_topic_score_gemma":0.009234714,"domain_scores_codex":[0.9995717,0.00007702317,0.00005413213,0.0000664777,0.0001497187,0.00008105112],"domain_scores_gemma":[0.9994507,0.000222529,0.00003814473,0.0001650571,0.00005657153,0.00006694998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002367852,0.00006847546,0.0002686141,0.00006789173,0.00001012665,0.0001663707,0.00002935957,0.00006195801,0.9965556,0.0002585726,0.0003372937,0.001939058],"study_design_scores_gemma":[0.00003732555,0.000257867,0.005029914,0.00001288477,0.00002940644,0.0004686147,0.00002425575,0.0006500637,0.9808499,0.00009330289,0.01253594,0.0000106092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7415364,0.02268104,0.1362068,0.001192772,0.0015066,0.001352724,0.04894328,0.003647064,0.04293333],"genre_scores_gemma":[0.7900034,0.01253935,0.07888986,0.0004599502,0.000249979,0.000729316,0.06041535,0.0006955686,0.05601736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005366869,"threshold_uncertainty_score":0.01468176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006609672070990984,"score_gpt":0.2504121470829148,"score_spread":0.2438024750119238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}