{"id":"W2031358152","doi":"10.1371/journal.pone.0021407","title":"A siRNA-Based Screen for Genes Involved in Chromosome End Protection","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of General Medical Sciences; National Institute on Aging; National Institutes of Health","keywords":"Shelterin; Telomere; Biology; Telomere-binding protein; Gene; DNA damage; Genetics; Phenotype; Rap1; Molecular biology; DNA; Cell biology; DNA-binding protein; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001852602,0.0007776942,0.000664119,0.0005426914,0.0003166349,0.0003195102,0.0004188813,0.0004816619,0.002713372],"category_scores_gemma":[0.0001214543,0.0002155968,0.0005525466,0.0003251204,0.0002364853,0.0001354616,0.0003229146,0.0005987828,0.00116085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002703361,"about_ca_system_score_gemma":0.0003757618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004709337,"about_ca_topic_score_gemma":0.001228567,"domain_scores_codex":[0.9996448,0.00003036794,0.0000351016,0.0001026382,0.0001452312,0.00004176528],"domain_scores_gemma":[0.9998612,0.00004256811,0.00002902257,0.00001564978,0.000021317,0.00003023712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003171421,0.00001506043,0.00008854809,0.00003996634,0.000008317756,0.00007805494,0.000005356168,0.00003472147,0.9986456,0.00004117885,0.00006640002,0.0009451018],"study_design_scores_gemma":[0.00004275777,0.0004115807,0.004952959,0.00001054515,0.000134226,0.0007429392,0.00002397912,0.001486063,0.9814364,0.00006709929,0.01067775,0.00001374676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9225479,0.005231099,0.04646757,0.0005192081,0.0003244885,0.0008074701,0.01352958,0.001148772,0.009423911],"genre_scores_gemma":[0.8817112,0.00601581,0.0482,0.0005892434,0.00006850761,0.001258846,0.02957914,0.000421544,0.03215566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002713372,"threshold_uncertainty_score":0.009077191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1590392382434506,"score_gpt":0.2536693897459042,"score_spread":0.09463015150245357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}