{"id":"W2031373255","doi":"10.1016/j.str.2010.09.022","title":"Structural and Biochemical Insights into MLL1 Core Complex Assembly","year":2011,"lang":"en","type":"article","venue":"Structure","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Methyltransferase; Ternary complex; Transferase; Protein subunit; Methylation; Biology; Chemistry; Stereochemistry; Genetics; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002979533,0.0004035631,0.0002384321,0.0002343728,0.0004203283,0.0007443676,0.0004159793,0.0004550395,0.001906352],"category_scores_gemma":[0.0004308751,0.0003572484,0.0002294664,0.0001852538,0.0003798829,0.0009525755,0.0003518473,0.001243313,0.0006242635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001000243,"about_ca_system_score_gemma":0.0003445842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008669036,"about_ca_topic_score_gemma":0.001603191,"domain_scores_codex":[0.9999241,0.00001265279,0.00000707107,0.00001640646,0.00002390007,0.000015866],"domain_scores_gemma":[0.9998883,0.00003069028,0.0000227654,0.00001490948,0.00001393509,0.00002935959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002075424,0.00004556453,0.000739573,0.000118292,0.0000091499,0.0002302254,0.00009936286,0.002985698,0.9779713,0.01054118,0.0004338218,0.006618451],"study_design_scores_gemma":[0.00001672067,0.00006599272,0.002057051,0.000009763678,0.00001330137,0.0003790887,0.0001008705,0.02264073,0.9616669,0.004269229,0.008761442,0.00001891589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9420126,0.006672336,0.03934226,0.00330401,0.0001684619,0.0000329502,0.0005585352,0.0005300799,0.007378799],"genre_scores_gemma":[0.9823139,0.00174812,0.01223244,0.0002455881,0.00003549009,0.00001741423,0.0005437728,0.00004212712,0.002821254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001906352,"threshold_uncertainty_score":0.007257283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02978528128552815,"score_gpt":0.2681280639725461,"score_spread":0.238342782687018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}