{"id":"W2031373255","doi":"10.1016/j.str.2010.09.022","title":"Structural and Biochemical Insights into MLL1 Core Complex Assembly","year":2011,"lang":"en","type":"article","venue":"Structure","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Methyltransferase; Ternary complex; Transferase; Protein subunit; Methylation; Biology; Chemistry; Stereochemistry; Genetics; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002543537,0.0001596868,0.0001201704,0.0000314171,0.00009068078,0.00001713207,0.0001259146,0.0002115956,0.00006094573],"category_scores_gemma":[0.00003001337,0.0001328617,0.00003844844,0.00005840535,0.0001132435,0.00000339206,0.000108022,0.00009430112,0.000001516739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000064873,"about_ca_system_score_gemma":0.00002207229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003080777,"about_ca_topic_score_gemma":0.00005149227,"domain_scores_codex":[0.9992674,0.00002240227,0.0001428931,0.0003146346,0.00009485574,0.0001578323],"domain_scores_gemma":[0.9995289,0.000004535322,0.00005878766,0.0002444975,0.00006431555,0.0000989926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003258278,0.000003691012,0.006248268,0.00001260021,0.00002160481,0.000001631164,0.0003177051,0.000001691787,0.9906752,0.0005034618,0.0001883301,0.001993211],"study_design_scores_gemma":[0.0004170352,0.0001872005,0.1453969,0.000006175269,0.00002027114,0.000009800135,0.0000664134,0.0002034934,0.8336821,0.01491047,0.004813328,0.0002868288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966336,0.002075763,0.0001692384,0.00001813683,0.0001371073,0.00009980849,0.00001260894,0.00001185543,0.0008418913],"genre_scores_gemma":[0.9949381,0.00009040356,0.004387016,0.00009725549,0.0001980227,0.000002131201,0.0002251835,0.00001791761,0.00004392567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1569932,"threshold_uncertainty_score":0.5417944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02978528128552815,"score_gpt":0.2681280639725461,"score_spread":0.238342782687018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}