{"id":"W2031387450","doi":"10.1074/jbc.m806674200","title":"NBCe1-A Transmembrane Segment 1 Lines the Ion Translocation Pathway","year":2009,"lang":"es","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; University of Toronto","keywords":"Chemistry; Transmembrane domain; Mutant; Chromosomal translocation; Cysteine; Transmembrane protein; Stereochemistry; Biochemistry; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005519121,0.0002458026,0.0002910526,0.00002333269,0.0001303782,0.00005832996,0.0002847611,0.0005277199,0.0001470952],"category_scores_gemma":[0.0001166078,0.0001434306,0.0003950636,0.0001283561,0.0001313441,0.000009470074,0.00001429459,0.0003328709,0.000005245524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003457048,"about_ca_system_score_gemma":0.0001084902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":5.355154e-7,"about_ca_topic_score_gemma":1.092938e-7,"domain_scores_codex":[0.998479,0.0001106172,0.0006851921,0.0002418296,0.0002517522,0.0002316162],"domain_scores_gemma":[0.9988734,0.00003367968,0.0004559428,0.0002099523,0.0002951707,0.0001318442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005629987,0.0002460417,0.00008695249,0.00003295237,0.00006140184,0.000006460616,0.00004951204,0.00041205,0.9590064,0.00002552614,0.0005446773,0.03896507],"study_design_scores_gemma":[0.0009942937,0.0008875652,0.001853406,0.00009077739,0.00003773727,0.0001825668,0.0001541375,0.0001513707,0.9358606,0.0001902682,0.05939942,0.0001978336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978783,0.006458981,0.005037009,0.008096433,0.0006225824,0.0001548065,0.00001714463,0.00001006376,0.00081998],"genre_scores_gemma":[0.9902436,0.005125668,0.0001252007,0.0005870938,0.003441352,0.000002279314,0.00008191977,0.000008839012,0.0003841079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05885474,"threshold_uncertainty_score":0.5848932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01956189530379067,"score_gpt":0.2488896666650599,"score_spread":0.2293277713612693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}