{"id":"W2031398056","doi":"10.1158/1538-7445.am2012-lb-449","title":"Abstract LB-449: KRAS mutation and amplification status predicts sensitivity to antifolate therapies in non-small-cell lung cancer","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"KRAS; Antifolate; Pemetrexed; Cancer research; Biology; Cancer; Mutation; Molecular biology; Antimetabolite; Chemotherapy; Gene; Genetics; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002889211,0.0001948055,0.0002719243,0.0007877219,0.0002358917,0.000537505,0.0001690303,0.0004917741,0.003404427],"category_scores_gemma":[0.0005539308,0.0001301926,0.0002722439,0.0004849859,0.0001497124,0.0001834288,0.0001750298,0.0003060201,0.0008515185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002461028,"about_ca_system_score_gemma":0.0001315988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001013138,"about_ca_topic_score_gemma":0.001410082,"domain_scores_codex":[0.9997846,0.00004258995,0.00003455209,0.0000409918,0.00007039536,0.00002679396],"domain_scores_gemma":[0.9995751,0.0001034032,0.0001332434,0.0000179677,0.00007021843,0.000100198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001862471,0.000178207,0.9134848,0.00005179536,0.00007295371,0.0003247303,0.00003383196,0.000140893,0.07708576,0.00002983522,0.0003184312,0.006416303],"study_design_scores_gemma":[0.000015253,0.0006216175,0.9769412,0.000009908479,0.00008207907,0.001643224,0.00008007685,0.001056588,0.01867609,0.00005287066,0.0008147625,0.000006352116],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977259,0.0008103756,0.0001329326,0.00006605945,0.00001003721,0.00001006226,0.0004040972,0.0000175746,0.0008230456],"genre_scores_gemma":[0.9989354,0.0001051572,0.0001023516,0.00002248422,0.000004887417,0.000005720742,0.000381207,0.000002424475,0.0004404256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003404427,"threshold_uncertainty_score":0.01138896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05520699532945354,"score_gpt":0.4316036562978303,"score_spread":0.3763966609683768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}