{"id":"W2031398283","doi":"10.1074/jbc.m109.029637","title":"Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser863 and Multisite Phosphorylation","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Cancer Society Research Institute; Terry Fox Foundation; University of Michigan; National Center for Research Resources; American Diabetes Association; American Heart Association; National Institutes of Health","keywords":"Phosphorylation; mTORC1; RHEB; Biology; Cell biology; PI3K/AKT/mTOR pathway; Phosphorylation cascade; Protein phosphorylation; Signal transduction; Protein kinase A; Protein kinase B","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002329613,0.0001320043,0.0002305819,0.0000135814,0.00003389112,0.00001143409,0.0001458697,0.0002627683,0.00009773995],"category_scores_gemma":[0.0001449057,0.0001042667,0.0001038225,0.00005463453,0.0001037878,0.0000063953,0.00002891328,0.0001331692,5.162424e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002620766,"about_ca_system_score_gemma":0.00002731891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001461397,"about_ca_topic_score_gemma":1.104631e-7,"domain_scores_codex":[0.9990957,0.00003296119,0.0004109635,0.0001806989,0.000144951,0.0001346736],"domain_scores_gemma":[0.9991169,0.00002435444,0.0004500797,0.0001347126,0.0001792612,0.00009471019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002767382,0.00006203752,0.003319147,0.00001358111,0.00002978307,0.000001218041,0.00000931135,0.0000384642,0.9900175,0.000003263019,0.003548997,0.002679975],"study_design_scores_gemma":[0.0006497386,0.0004898581,0.0207719,0.00002750174,0.00001539424,0.00004245321,0.00001630579,0.00006602763,0.9685138,0.0001319707,0.009149175,0.0001258548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963522,0.002252773,0.0008817707,0.0001345696,0.00004850755,0.00005088442,0.00002650296,0.000004870365,0.000247934],"genre_scores_gemma":[0.9977263,0.0002844663,0.001304902,0.0001365305,0.0003410436,8.174983e-7,0.00006832737,0.000006208037,0.0001314287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02150366,"threshold_uncertainty_score":0.4251872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01751526992923998,"score_gpt":0.2624148309105496,"score_spread":0.2448995609813097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}