{"id":"W2031431983","doi":"10.1007/s00147-004-0716-5","title":"Maximizing the clinical outcome with mTOR inhibitors in the renal transplant recipient: defining the role of calcineurin inhibitors","year":2004,"lang":"en","type":"review","venue":"Transplant International","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Dalhousie University","funders":"","keywords":"Calcineurin; Everolimus; Medicine; Sirolimus; Nephrotoxicity; Pharmacology; Regimen; PI3K/AKT/mTOR pathway; Tacrolimus; Renal function; Urology; Discovery and development of mTOR inhibitors; Toxicity; Transplantation; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001125373,0.0005976353,0.001374544,0.0002735758,0.0001481111,0.00005606608,0.0008187924,0.0002746547,0.00006131937],"category_scores_gemma":[0.00002580766,0.0002357374,0.001012733,0.000414687,0.0002688349,0.00009153382,0.00001815984,0.001360563,0.0000322064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001441552,"about_ca_system_score_gemma":0.0003712002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002559099,"about_ca_topic_score_gemma":0.0001841615,"domain_scores_codex":[0.9954268,0.0004042107,0.002069483,0.000530454,0.001174543,0.0003945032],"domain_scores_gemma":[0.9972852,0.001411106,0.0006241336,0.0004987169,0.00008140574,0.0000994666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004515845,0.00353357,0.3557598,0.01925276,0.009191793,0.005502721,0.01385332,0.0004881842,0.00001070985,0.02479767,0.00008992253,0.5630037],"study_design_scores_gemma":[0.01563182,0.001707467,0.03578763,0.2138821,0.01481945,0.01475023,0.000740715,0.00008751595,0.0001293136,0.0003416405,0.700543,0.00157915],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00526975,0.9811792,0.0001990178,0.001971388,0.0015108,0.0036848,0.001843508,0.00007366784,0.004267878],"genre_scores_gemma":[0.1316721,0.8659458,0.0002297938,0.0002543455,0.0003683259,0.0002307984,0.001105322,0.00007510366,0.0001183844],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.700453,"threshold_uncertainty_score":0.9613091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06263981730043171,"score_gpt":0.3722335406722289,"score_spread":0.3095937233717972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}