{"id":"W2031456207","doi":"10.1097/mjt.0b013e318160c1b7","title":"Pathogen Safety of Intravenous Rh Immunoglobulin Liquid and Other Immune Globulin Products: Enhanced Nanofiltration and Manufacturing Process Overview","year":2008,"lang":"en","type":"review","venue":"American Journal of Therapeutics","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Manitoba","funders":"","keywords":"Nanofiltration; Antibody; Filtration (mathematics); Medicine; Contamination; Process validation; Chromatography; Manufacturing process; Membrane; Chemistry; Materials science; Immunology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001645703,0.0006321945,0.0002967106,0.0005798098,0.0002865395,0.0007250866,0.0005056018,0.0006256507,0.0009387266],"category_scores_gemma":[0.0006837982,0.0001737382,0.0005968072,0.0002925221,0.0002304034,0.0006130266,0.0003597126,0.0005203863,0.0004810808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007926732,"about_ca_system_score_gemma":0.0009681156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001846759,"about_ca_topic_score_gemma":0.001232721,"domain_scores_codex":[0.9991083,0.0001193109,0.00008746213,0.0000953984,0.0005367657,0.00005281696],"domain_scores_gemma":[0.9996027,0.00007885683,0.0001071505,0.00002599311,0.0001719299,0.00001334412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001773475,0.0001781616,0.001580877,0.0008793559,0.00001909945,0.0001903482,0.0001097196,0.001484665,0.9282583,0.0007310958,0.0004139322,0.06597704],"study_design_scores_gemma":[0.00001618937,0.001053654,0.005610195,0.0001020172,0.00004637875,0.0006252688,0.00005389581,0.004447588,0.9651039,0.0002340248,0.02267434,0.00003261268],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7922495,0.02572558,0.162924,0.001002805,0.0001985591,0.001716691,0.001170482,0.0008585375,0.01415387],"genre_scores_gemma":[0.6941495,0.02831699,0.265127,0.0004374646,0.0001693707,0.0008800238,0.002690587,0.0002087217,0.008020284],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001846759,"threshold_uncertainty_score":0.008703411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02125408885238033,"score_gpt":0.3055299572646181,"score_spread":0.2842758684122378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}